Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma

J. C. Bernini; D. W. Fort; M. Pritchard; B. B. Rogers; N. J. Winick

doi:10.1002/1097-0142(19940801)74:3<962::AID-CNCR2820740327>3.0.CO;2-A

Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma

J. C. Bernini, D. W. Fort, M. Pritchard, B. B. Rogers, N. J. Winick

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17 Scopus citations

Abstract

Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.

Original language	English (US)
Pages (from-to)	962-964
Number of pages	3
Journal	Cancer
Volume	74
Issue number	3
DOIs	https://doi.org/10.1002/1097-0142(19940801)74:3<962::AID-CNCR2820740327>3.0.CO;2-A
State	Published - Aug 1 1994

Keywords

angiomatoid malignant fibrous histiocytoma
children
malignant fibrous histiocytoma
sarcoma

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19940801)74:3<962::AID-CNCR2820740327>3.0.CO;2-A

Cite this

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title = "Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma",

abstract = "Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.",

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AU - Bernini, J. C.

AU - Fort, D. W.

AU - Pritchard, M.

AU - Rogers, B. B.

AU - Winick, N. J.

PY - 1994/8/1

Y1 - 1994/8/1

N2 - Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.

AB - Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.

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KW - children

KW - malignant fibrous histiocytoma

KW - sarcoma

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Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma

Abstract

Keywords

ASJC Scopus subject areas

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