Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma

J. C. Bernini, D. W. Fort, M. Pritchard, B. B. Rogers, N. J. Winick

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.

Original languageEnglish (US)
Pages (from-to)962-964
Number of pages3
JournalCancer
Volume74
Issue number3 SUPPL.
DOIs
StatePublished - 1994

Fingerprint

Malignant Fibrous Histiocytoma
Adjuvant Chemotherapy
Drug Therapy
Dactinomycin
Vincristine
Sarcoma
Doxorubicin
Cyclophosphamide
Therapeutics
Angiomatoid Fibrous Histiocytoma
Neoplasms

Keywords

  • angiomatoid malignant fibrous histiocytoma
  • children
  • malignant fibrous histiocytoma
  • sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma. / Bernini, J. C.; Fort, D. W.; Pritchard, M.; Rogers, B. B.; Winick, N. J.

In: Cancer, Vol. 74, No. 3 SUPPL., 1994, p. 962-964.

Research output: Contribution to journalArticle

Bernini, J. C. ; Fort, D. W. ; Pritchard, M. ; Rogers, B. B. ; Winick, N. J. / Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma. In: Cancer. 1994 ; Vol. 74, No. 3 SUPPL. pp. 962-964.
@article{9666b541ec994d7080f05085782c7d9c,
title = "Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma",
abstract = "Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.",
keywords = "angiomatoid malignant fibrous histiocytoma, children, malignant fibrous histiocytoma, sarcoma",
author = "Bernini, {J. C.} and Fort, {D. W.} and M. Pritchard and Rogers, {B. B.} and Winick, {N. J.}",
year = "1994",
doi = "10.1002/1097-0142(19940801)74:3<962::AID-CNCR2820740327>3.0.CO;2-A",
language = "English (US)",
volume = "74",
pages = "962--964",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "3 SUPPL.",

}

TY - JOUR

T1 - Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma

AU - Bernini, J. C.

AU - Fort, D. W.

AU - Pritchard, M.

AU - Rogers, B. B.

AU - Winick, N. J.

PY - 1994

Y1 - 1994

N2 - Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.

AB - Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult patient has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristine, doxorubicin, dactinomycin, and cyclophosphamide. A complete response at the metastatic site and a marked reduction in the size of the primary tumor allowed complete surgical excision 7 months after treatment was initiated. The patient remains disease free 19 months after being diagnosed. It was concluded that systemic chemotherapy may be effective in patients with AMFH.

KW - angiomatoid malignant fibrous histiocytoma

KW - children

KW - malignant fibrous histiocytoma

KW - sarcoma

UR - http://www.scopus.com/inward/record.url?scp=0028001032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028001032&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19940801)74:3<962::AID-CNCR2820740327>3.0.CO;2-A

DO - 10.1002/1097-0142(19940801)74:3<962::AID-CNCR2820740327>3.0.CO;2-A

M3 - Article

C2 - 8039125

AN - SCOPUS:0028001032

VL - 74

SP - 962

EP - 964

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 3 SUPPL.

ER -