Adjuvant chemotherapy with doxorubicin and cyclophosphamide in women with rapidly proliferating node-negative breast cancer

Stephen E. Jones, Gary Clark, Sherry Koleszar, Gaby Ethington, Robert Mennel, Steven Paulson, Barry Brooks, Ronald Kerr, Claude Denham, Michael Savin, Joanne Blum, Robert Kirby, Marvin Stone, John Pippen, Timothy George, Douglas Orr, Sally Knox, Michael Grant, George Peters, Daniel SavinoCharles Rietz

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

This prospective clinical trial was designed to assess the impact of adjuvant chemotherapy in women with rapidly proliferating node-negative breast cancer. This group has been predicted to have a 5-year disease-free survival (DFS) of 70% without adjuvant chemotherapy. In this study, 449 women with rapidly proliferating breast cancer (91% measured by S-phase fraction and 9% by histochemistry) received adjuvant chemotherapy with doxorubicin/cyclophosphamide (AC) plus tamoxifen for estrogen receptor-positive or progesterone receptor-positive cancer. The 5-year DFS was 90%

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalClinical Breast Cancer
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • Estrogen receptor
  • Progesterone receptor
  • Tamoxifen
  • Thymidine phosphorylase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Jones, S. E., Clark, G., Koleszar, S., Ethington, G., Mennel, R., Paulson, S., Brooks, B., Kerr, R., Denham, C., Savin, M., Blum, J., Kirby, R., Stone, M., Pippen, J., George, T., Orr, D., Knox, S., Grant, M., Peters, G., ... Rietz, C. (2002). Adjuvant chemotherapy with doxorubicin and cyclophosphamide in women with rapidly proliferating node-negative breast cancer. Clinical Breast Cancer, 3(2), 147-152. https://doi.org/10.3816/CBC.2002.n.019