Abstract
Background: There is limited information on optimization of symptomatic management of cervical dystonia (CD) after implantation of pallidal deep brain stimulation (DBS). Objectives: To describe the long-term, “real-world” management of CD patients after DBS implantation and the role of reintroduction of pharmacologic and botulinum toxin (BoNT) therapy. Methods: A retrospective analysis of patients with focal cervical or segmental craniocervical dystonia implanted with DBS was conducted. Results: Nine patients were identified with a mean follow-up of 41.7 ± 15.7 months. All patients continued adjuvant oral medication(s) to optimize symptom control post-operatively. Three stopped BoNT and four reduced BoNT dose by an average of 22%. All patients remained on at least one medication used to treat dystonia post-operatively. Conclusion: Optimal symptom control was achieved with DBS combined with either BoNT and/or medication. We suggest utilization of adjuvant therapies such as BoNT and/or medications if DBS monotherapy does not achieve optimal symptom control.
Original language | English (US) |
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Article number | 927573 |
Journal | Frontiers in Neurology |
Volume | 13 |
DOIs | |
State | Published - Aug 5 2022 |
Externally published | Yes |
Keywords
- botulinum toxin
- cervical dystonia
- deep brain stimulation
- long-term follow up
- medical therapy
ASJC Scopus subject areas
- Neurology
- Clinical Neurology