Adolescent and Parent Willingness to Participate in Microbicide Safety Studies

Marina Catallozzi, Ariel M. de Roche, Mei Chen Hu, Carmen Radecki Breitkopf, Jane Chang, Lisa S. Ipp, Jenny K.R. Francis, Susan L. Rosenthal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Study Objective To understand adolescents’ and parents’ willingness to participate (WTP) in a hypothetical phase I prevention study of sexually transmitted infections, discordance within adolescent-parent dyads, and expectations of each other during decision-making. Design and Setting Adolescent-parent dyads were recruited to participate in a longitudinal study about research participation attitudes. Participants Adolescents (14-17 years old) and their parents (n = 301 dyads) participated. Interventions None. Main Outcome Measures Individual interviews at baseline assessed WTP on a 6-level Likert scale. WTP was dichotomized (willing/unwilling) to assess discordance. Results WTP was reported by 60% (182 of 301) of adolescents and 52% (156 of 300) of parents. In bivariate analyses, older adolescent age, sexual experience, and less involvement of parents in research processes were associated with higher level of WTP for adolescents; only sexual experience remained in the multivariable analysis. For parents, older adolescent age, perceived adolescent sexual experience, and conversations about sexual health were significant; only conversations remained. Dyadic discordance (44%, 132 of 300) was more likely in dyads in which the parent reported previous research experience, and less likely when parents reported higher family expressiveness. Adolescents (83%, 248 of 299) and parents (88%, 263 of 300) thought that the other would have similar views, influence their decision (adolescents 66%, 199 of 300; parents 75%, 224 of 300), and listen (adolescents 90%, 270 of 300; parents 96%, 287 of 300). There were no relationships between these perceptions and discordance. Conclusion Inclusion of adolescents in phase I clinical trials is necessary to ensure that new methods are safe, effective, and acceptable for them. Because these trials currently require parental consent, strategies that manage adolescent-parent discordance and support adolescent independence and parental guidance are critically needed.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalJournal of Pediatric and Adolescent Gynecology
Volume30
Issue number1
DOIs
StatePublished - Feb 1 2017

Fingerprint

Anti-Infective Agents
Safety
Parents
Research
Parental Consent
Clinical Trials, Phase I
Reproductive Health
Sexually Transmitted Diseases
Longitudinal Studies
Decision Making

Keywords

  • Adolescent research participation
  • Clinical trials
  • Sexually transmitted infections
  • Topical microbicides

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Catallozzi, M., de Roche, A. M., Hu, M. C., Breitkopf, C. R., Chang, J., Ipp, L. S., ... Rosenthal, S. L. (2017). Adolescent and Parent Willingness to Participate in Microbicide Safety Studies. Journal of Pediatric and Adolescent Gynecology, 30(1), 82-87. https://doi.org/10.1016/j.jpag.2016.06.009

Adolescent and Parent Willingness to Participate in Microbicide Safety Studies. / Catallozzi, Marina; de Roche, Ariel M.; Hu, Mei Chen; Breitkopf, Carmen Radecki; Chang, Jane; Ipp, Lisa S.; Francis, Jenny K.R.; Rosenthal, Susan L.

In: Journal of Pediatric and Adolescent Gynecology, Vol. 30, No. 1, 01.02.2017, p. 82-87.

Research output: Contribution to journalArticle

Catallozzi, M, de Roche, AM, Hu, MC, Breitkopf, CR, Chang, J, Ipp, LS, Francis, JKR & Rosenthal, SL 2017, 'Adolescent and Parent Willingness to Participate in Microbicide Safety Studies', Journal of Pediatric and Adolescent Gynecology, vol. 30, no. 1, pp. 82-87. https://doi.org/10.1016/j.jpag.2016.06.009
Catallozzi, Marina ; de Roche, Ariel M. ; Hu, Mei Chen ; Breitkopf, Carmen Radecki ; Chang, Jane ; Ipp, Lisa S. ; Francis, Jenny K.R. ; Rosenthal, Susan L. / Adolescent and Parent Willingness to Participate in Microbicide Safety Studies. In: Journal of Pediatric and Adolescent Gynecology. 2017 ; Vol. 30, No. 1. pp. 82-87.
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abstract = "Study Objective To understand adolescents’ and parents’ willingness to participate (WTP) in a hypothetical phase I prevention study of sexually transmitted infections, discordance within adolescent-parent dyads, and expectations of each other during decision-making. Design and Setting Adolescent-parent dyads were recruited to participate in a longitudinal study about research participation attitudes. Participants Adolescents (14-17 years old) and their parents (n = 301 dyads) participated. Interventions None. Main Outcome Measures Individual interviews at baseline assessed WTP on a 6-level Likert scale. WTP was dichotomized (willing/unwilling) to assess discordance. Results WTP was reported by 60{\%} (182 of 301) of adolescents and 52{\%} (156 of 300) of parents. In bivariate analyses, older adolescent age, sexual experience, and less involvement of parents in research processes were associated with higher level of WTP for adolescents; only sexual experience remained in the multivariable analysis. For parents, older adolescent age, perceived adolescent sexual experience, and conversations about sexual health were significant; only conversations remained. Dyadic discordance (44{\%}, 132 of 300) was more likely in dyads in which the parent reported previous research experience, and less likely when parents reported higher family expressiveness. Adolescents (83{\%}, 248 of 299) and parents (88{\%}, 263 of 300) thought that the other would have similar views, influence their decision (adolescents 66{\%}, 199 of 300; parents 75{\%}, 224 of 300), and listen (adolescents 90{\%}, 270 of 300; parents 96{\%}, 287 of 300). There were no relationships between these perceptions and discordance. Conclusion Inclusion of adolescents in phase I clinical trials is necessary to ensure that new methods are safe, effective, and acceptable for them. Because these trials currently require parental consent, strategies that manage adolescent-parent discordance and support adolescent independence and parental guidance are critically needed.",
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