Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil β2-adrenergic receptors: G(s) protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severity

George N M Gurguis, Kimberly A. Yonkers, Jaishri E. Blakeley, Stephanie P. Phan, Anita Williams, A. John Rush

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Abnormal β2-adrenergic receptor coupling to G(s) protein is implicated in depressive disorders. Steroid hormones and antidepressants modulate β- adrenergic receptor coupling, which may relate to the therapeutic efficacy of antidepressants. We examined β2-adrenergic receptors in 18 patients with premenstrual dysphoric disorder (PMDD), in 15 control subjects during the follicular phase and in 12 patients during late luteal phase. Antagonist- measured receptor density, agonist-measured receptor density in the high- and low-conformational states and agonist affinity to both states were measured. Coupling indices to Gs protein were determined from agonist-displacement experiments. Follicular β2-adrenergic receptor density was higher in patients than in control subjects, with a trend for higher receptor density in the high-conformational state. The phase of menstrual cycle had no effect on β2-adrenergic receptor regulation in PMDD. Exploratory correlations showed that the K(L)/K(H) ratio was related to anxiety ratings in control subjects and %R(H) was correlated with symptom severity in patients. In patients, follicular β2-adrenergic receptor binding measures were correlated with luteal symptom severity. These findings suggest abnormal β2-adrenergic receptor regulation in PMDD. Further exploration of the role of β-adrenergic receptor kinase, sex steroid hormones and antidepressants on β-adrenergic receptor regulation in PMDD is warranted.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalPsychiatry research
Volume79
Issue number1
DOIs
StatePublished - Jun 2 1998

Keywords

  • Anxiety
  • Coupling
  • Depression
  • G(s) protein
  • Premenstrual syndrome
  • β-Adrenergic receptors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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