TY - JOUR
T1 - Adult hippocampal neurogenesis for systems consolidation of memory
AU - Terranova, Joseph I.
AU - Ogawa, Sachie K.
AU - Kitamura, Takashi
N1 - Funding Information:
We thank all members of the Kitamura laboratory for their support. The Kitamura laboratory was supported by grants from Endowed Scholar Program (T.K), Human Frontier Science Program (T.K), Brain Research Foundation (T.K), Faculty Science and Technology Acquisition and Retention Program (T.K), Mary and John Osterhaus for their donation and to the Brain & Behavior Research Foundation (T.K), and The Whitehall Foundation (T.K).
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/10/17
Y1 - 2019/10/17
N2 - The hippocampus (HPC) is required for the initial process of permanent memory formation. After memory acquisition, HPC-dependency of memory recall gradually decreases with time, whereas cortical-dependency of memory recall increases. This phenomenon is often referred to as systems consolidation of memory. In the HPC, adult neurogenesis has been described in many mammalian species and is involved in the process of learning and memory. In this review, we first examine the neural circuit mechanisms that underlie the systems consolidation of episodic memories, focusing on adult neurogenesis within the HPC. Recently, several studies have examined the characterization of memory engram cells, their biochemical and physiological changes, and the circuits for systems consolidation of memory. Therefore, we discuss the possible role of adult neurogenesis on functional states of memory engram cells, and speculate the implications of this transition of memory type for psychiatric disorders such as post-traumatic stress disorder.
AB - The hippocampus (HPC) is required for the initial process of permanent memory formation. After memory acquisition, HPC-dependency of memory recall gradually decreases with time, whereas cortical-dependency of memory recall increases. This phenomenon is often referred to as systems consolidation of memory. In the HPC, adult neurogenesis has been described in many mammalian species and is involved in the process of learning and memory. In this review, we first examine the neural circuit mechanisms that underlie the systems consolidation of episodic memories, focusing on adult neurogenesis within the HPC. Recently, several studies have examined the characterization of memory engram cells, their biochemical and physiological changes, and the circuits for systems consolidation of memory. Therefore, we discuss the possible role of adult neurogenesis on functional states of memory engram cells, and speculate the implications of this transition of memory type for psychiatric disorders such as post-traumatic stress disorder.
KW - Adult neurogenesis
KW - Fear conditioning
KW - Hippocampus
KW - Medial prefrontal cortex
KW - Memory consolidation
KW - Memory engram
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U2 - 10.1016/j.bbr.2019.112035
DO - 10.1016/j.bbr.2019.112035
M3 - Review article
C2 - 31201874
AN - SCOPUS:85067619579
VL - 372
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
M1 - 112035
ER -