Adult hippocampal neurogenesis for systems consolidation of memory

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The hippocampus (HPC) is required for the initial process of permanent memory formation. After memory acquisition, HPC-dependency of memory recall gradually decreases with time, whereas cortical-dependency of memory recall increases. This phenomenon is often referred to as systems consolidation of memory. In the HPC, adult neurogenesis has been described in many mammalian species and is involved in the process of learning and memory. In this review, we first examine the neural circuit mechanisms that underlie the systems consolidation of episodic memories, focusing on adult neurogenesis within the HPC. Recently, several studies have examined the characterization of memory engram cells, their biochemical and physiological changes, and the circuits for systems consolidation of memory. Therefore, we discuss the possible role of adult neurogenesis on functional states of memory engram cells, and speculate the implications of this transition of memory type for psychiatric disorders such as post-traumatic stress disorder.

Original languageEnglish (US)
Article number112035
JournalBehavioural Brain Research
Volume372
DOIs
StatePublished - Oct 17 2019

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Neurogenesis
Hippocampus
Episodic Memory
Memory Disorders
Post-Traumatic Stress Disorders
Memory Consolidation
Psychiatry
Learning

Keywords

  • Adult neurogenesis
  • Fear conditioning
  • Hippocampus
  • Medial prefrontal cortex
  • Memory consolidation
  • Memory engram

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Adult hippocampal neurogenesis for systems consolidation of memory. / Terranova, Joseph I.; Kitamura, Sachie Ogawa; Kitamura, Takashi.

In: Behavioural Brain Research, Vol. 372, 112035, 17.10.2019.

Research output: Contribution to journalReview article

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