Adult hippocampal neurogenesis for systems consolidation of memory

Joseph I. Terranova, Sachie K. Ogawa, Takashi Kitamura

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The hippocampus (HPC) is required for the initial process of permanent memory formation. After memory acquisition, HPC-dependency of memory recall gradually decreases with time, whereas cortical-dependency of memory recall increases. This phenomenon is often referred to as systems consolidation of memory. In the HPC, adult neurogenesis has been described in many mammalian species and is involved in the process of learning and memory. In this review, we first examine the neural circuit mechanisms that underlie the systems consolidation of episodic memories, focusing on adult neurogenesis within the HPC. Recently, several studies have examined the characterization of memory engram cells, their biochemical and physiological changes, and the circuits for systems consolidation of memory. Therefore, we discuss the possible role of adult neurogenesis on functional states of memory engram cells, and speculate the implications of this transition of memory type for psychiatric disorders such as post-traumatic stress disorder.

Original languageEnglish (US)
Article number112035
JournalBehavioural Brain Research
StatePublished - Oct 17 2019


  • Adult neurogenesis
  • Fear conditioning
  • Hippocampus
  • Medial prefrontal cortex
  • Memory consolidation
  • Memory engram

ASJC Scopus subject areas

  • Behavioral Neuroscience


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