Abstract
The hippocampus (HPC) is required for the initial process of permanent memory formation. After memory acquisition, HPC-dependency of memory recall gradually decreases with time, whereas cortical-dependency of memory recall increases. This phenomenon is often referred to as systems consolidation of memory. In the HPC, adult neurogenesis has been described in many mammalian species and is involved in the process of learning and memory. In this review, we first examine the neural circuit mechanisms that underlie the systems consolidation of episodic memories, focusing on adult neurogenesis within the HPC. Recently, several studies have examined the characterization of memory engram cells, their biochemical and physiological changes, and the circuits for systems consolidation of memory. Therefore, we discuss the possible role of adult neurogenesis on functional states of memory engram cells, and speculate the implications of this transition of memory type for psychiatric disorders such as post-traumatic stress disorder.
| Original language | English (US) |
|---|---|
| Article number | 112035 |
| Journal | Behavioural Brain Research |
| Volume | 372 |
| DOIs | |
| State | Published - Oct 17 2019 |
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Keywords
- Adult neurogenesis
- Fear conditioning
- Hippocampus
- Medial prefrontal cortex
- Memory consolidation
- Memory engram
ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Adult hippocampal neurogenesis for systems consolidation of memory. / Terranova, Joseph I.; Kitamura, Sachie Ogawa; Kitamura, Takashi.
In: Behavioural Brain Research, Vol. 372, 112035, 17.10.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Adult hippocampal neurogenesis for systems consolidation of memory
AU - Terranova, Joseph I.
AU - Kitamura, Sachie Ogawa
AU - Kitamura, Takashi
PY - 2019/10/17
Y1 - 2019/10/17
N2 - The hippocampus (HPC) is required for the initial process of permanent memory formation. After memory acquisition, HPC-dependency of memory recall gradually decreases with time, whereas cortical-dependency of memory recall increases. This phenomenon is often referred to as systems consolidation of memory. In the HPC, adult neurogenesis has been described in many mammalian species and is involved in the process of learning and memory. In this review, we first examine the neural circuit mechanisms that underlie the systems consolidation of episodic memories, focusing on adult neurogenesis within the HPC. Recently, several studies have examined the characterization of memory engram cells, their biochemical and physiological changes, and the circuits for systems consolidation of memory. Therefore, we discuss the possible role of adult neurogenesis on functional states of memory engram cells, and speculate the implications of this transition of memory type for psychiatric disorders such as post-traumatic stress disorder.
AB - The hippocampus (HPC) is required for the initial process of permanent memory formation. After memory acquisition, HPC-dependency of memory recall gradually decreases with time, whereas cortical-dependency of memory recall increases. This phenomenon is often referred to as systems consolidation of memory. In the HPC, adult neurogenesis has been described in many mammalian species and is involved in the process of learning and memory. In this review, we first examine the neural circuit mechanisms that underlie the systems consolidation of episodic memories, focusing on adult neurogenesis within the HPC. Recently, several studies have examined the characterization of memory engram cells, their biochemical and physiological changes, and the circuits for systems consolidation of memory. Therefore, we discuss the possible role of adult neurogenesis on functional states of memory engram cells, and speculate the implications of this transition of memory type for psychiatric disorders such as post-traumatic stress disorder.
KW - Adult neurogenesis
KW - Fear conditioning
KW - Hippocampus
KW - Medial prefrontal cortex
KW - Memory consolidation
KW - Memory engram
UR - http://www.scopus.com/inward/record.url?scp=85067619579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067619579&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2019.112035
DO - 10.1016/j.bbr.2019.112035
M3 - Review article
C2 - 31201874
AN - SCOPUS:85067619579
VL - 372
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
M1 - 112035
ER -