Adult neurogenesis, mental health, and mental illness: Hope or hype?

Amelia J. Eisch, Heather A. Cameron, Juan M. Encinas, Leslie A. Meltzer, Guo Li Ming, Linda S. Overstreet-Wadiche

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding "normal" adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.

Original languageEnglish (US)
Pages (from-to)11785-11791
Number of pages7
JournalJournal of Neuroscience
Volume28
Issue number46
DOIs
StatePublished - Nov 12 2008

Fingerprint

Hope
Neurogenesis
Mental Health
Nervous System Diseases
Psychiatry
Schizophrenia
Post-Traumatic Epilepsy
Research Personnel
Depression
Adult Stem Cells
Self Administration
Cell Aging
Dentate Gyrus
Life Cycle Stages
Cocaine
Antidepressive Agents

Keywords

  • Addiction
  • Depression
  • Epilepsy
  • Learning
  • Neural stem cell
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G. L., & Overstreet-Wadiche, L. S. (2008). Adult neurogenesis, mental health, and mental illness: Hope or hype? Journal of Neuroscience, 28(46), 11785-11791. https://doi.org/10.1523/JNEUROSCI.3798-08.2008

Adult neurogenesis, mental health, and mental illness : Hope or hype? / Eisch, Amelia J.; Cameron, Heather A.; Encinas, Juan M.; Meltzer, Leslie A.; Ming, Guo Li; Overstreet-Wadiche, Linda S.

In: Journal of Neuroscience, Vol. 28, No. 46, 12.11.2008, p. 11785-11791.

Research output: Contribution to journalArticle

Eisch, AJ, Cameron, HA, Encinas, JM, Meltzer, LA, Ming, GL & Overstreet-Wadiche, LS 2008, 'Adult neurogenesis, mental health, and mental illness: Hope or hype?', Journal of Neuroscience, vol. 28, no. 46, pp. 11785-11791. https://doi.org/10.1523/JNEUROSCI.3798-08.2008
Eisch AJ, Cameron HA, Encinas JM, Meltzer LA, Ming GL, Overstreet-Wadiche LS. Adult neurogenesis, mental health, and mental illness: Hope or hype? Journal of Neuroscience. 2008 Nov 12;28(46):11785-11791. https://doi.org/10.1523/JNEUROSCI.3798-08.2008
Eisch, Amelia J. ; Cameron, Heather A. ; Encinas, Juan M. ; Meltzer, Leslie A. ; Ming, Guo Li ; Overstreet-Wadiche, Linda S. / Adult neurogenesis, mental health, and mental illness : Hope or hype?. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 46. pp. 11785-11791.
@article{4a10271e4e4e4173b92b3b06924e244e,
title = "Adult neurogenesis, mental health, and mental illness: Hope or hype?",
abstract = "Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding {"}normal{"} adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.",
keywords = "Addiction, Depression, Epilepsy, Learning, Neural stem cell, Schizophrenia",
author = "Eisch, {Amelia J.} and Cameron, {Heather A.} and Encinas, {Juan M.} and Meltzer, {Leslie A.} and Ming, {Guo Li} and Overstreet-Wadiche, {Linda S.}",
year = "2008",
month = "11",
day = "12",
doi = "10.1523/JNEUROSCI.3798-08.2008",
language = "English (US)",
volume = "28",
pages = "11785--11791",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "46",

}

TY - JOUR

T1 - Adult neurogenesis, mental health, and mental illness

T2 - Hope or hype?

AU - Eisch, Amelia J.

AU - Cameron, Heather A.

AU - Encinas, Juan M.

AU - Meltzer, Leslie A.

AU - Ming, Guo Li

AU - Overstreet-Wadiche, Linda S.

PY - 2008/11/12

Y1 - 2008/11/12

N2 - Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding "normal" adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.

AB - Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding "normal" adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.

KW - Addiction

KW - Depression

KW - Epilepsy

KW - Learning

KW - Neural stem cell

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=58149343358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149343358&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.3798-08.2008

DO - 10.1523/JNEUROSCI.3798-08.2008

M3 - Article

C2 - 19005040

AN - SCOPUS:58149343358

VL - 28

SP - 11785

EP - 11791

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 46

ER -