TY - JOUR
T1 - Advanced Glycation End Products and Risks for Chronic Diseases
T2 - Intervening Through Lifestyle Modification
AU - Prasad, Chandan
AU - Davis, Kathleen E.
AU - Imrhan, Victorine
AU - Juma, Shanil
AU - Vijayagopal, Parakat
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Advanced glycation end products (AGEs) are a family of compounds of diverse chemical nature that are the products of nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs bind to one or more of their multiple receptors (RAGE) found on a variety of cell types and elicit an array of biologic responses. In this review, we have summarized the data on the nature of AGEs and issues associated with their measurements, their receptors, and changes in their expression under different physiologic and disease states. Last, we have used this information to prescribe lifestyle choices to modulate AGE-RAGE cycle for better health.
AB - Advanced glycation end products (AGEs) are a family of compounds of diverse chemical nature that are the products of nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs bind to one or more of their multiple receptors (RAGE) found on a variety of cell types and elicit an array of biologic responses. In this review, we have summarized the data on the nature of AGEs and issues associated with their measurements, their receptors, and changes in their expression under different physiologic and disease states. Last, we have used this information to prescribe lifestyle choices to modulate AGE-RAGE cycle for better health.
KW - AGEs
KW - advanced glycation end products
KW - diet
KW - inflammation
KW - lifestyle
UR - http://www.scopus.com/inward/record.url?scp=85041488274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041488274&partnerID=8YFLogxK
U2 - 10.1177/1559827617708991
DO - 10.1177/1559827617708991
M3 - Review article
C2 - 31285723
AN - SCOPUS:85041488274
SN - 1559-8276
VL - 13
SP - 384
EP - 404
JO - American Journal of Lifestyle Medicine
JF - American Journal of Lifestyle Medicine
IS - 4
ER -