Advanced Glycation End Products and Risks for Chronic Diseases: Intervening Through Lifestyle Modification

Chandan Prasad, Kathleen E Davis, Victorine Imrhan, Shanil Juma, Parakat Vijayagopal

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Advanced glycation end products (AGEs) are a family of compounds of diverse chemical nature that are the products of nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs bind to one or more of their multiple receptors (RAGE) found on a variety of cell types and elicit an array of biologic responses. In this review, we have summarized the data on the nature of AGEs and issues associated with their measurements, their receptors, and changes in their expression under different physiologic and disease states. Last, we have used this information to prescribe lifestyle choices to modulate AGE-RAGE cycle for better health.

Original languageEnglish (US)
Pages (from-to)384-404
Number of pages21
JournalAmerican Journal of Lifestyle Medicine
Volume13
Issue number4
DOIs
StatePublished - Jul 1 2019

Keywords

  • advanced glycation end products
  • AGEs
  • diet
  • inflammation
  • lifestyle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health Policy
  • Public Health, Environmental and Occupational Health

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