@article{528d8f843ce84ec1a0b3067bc0e25e5a,
title = "Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations",
abstract = "Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains largely confined to the research community and a limited number of clinical sites. The MRSI methods currently implemented on clinical MRI instruments have remained essentially unchanged for two decades, with only incremental improvements in sequence implementation. During this time, a number of technological developments have taken place that have already greatly benefited the quality of MRSI measurements within the research community and which promise to bring advanced MRSI studies to the point where the technique becomes a true imaging modality, while making the traditional review of individual spectra a secondary requirement. Furthermore, the increasing use of biomedical MR spectroscopy studies has indicated clinical areas where advanced MRSI methods can provide valuable information for clinical care. In light of this rapidly changing technological environment and growing understanding of the value of MRSI studies for biomedical studies, this article presents a consensus from a group of experts in the field that reviews the state-of-the-art for clinical proton MRSI studies of the human brain, recommends minimal standards for further development of vendor-provided MRSI implementations, and identifies areas which need further technical development.",
keywords = "brain, magnetic resonance spectroscopic imaging, review",
author = "Maudsley, {Andrew A.} and Andronesi, {Ovidiu C.} and Barker, {Peter B.} and Alberto Bizzi and Wolfgang Bogner and Anke Henning and Nelson, {Sarah J.} and Stefan Posse and Shungu, {Dikoma C.} and Soher, {Brian J.}",
note = "Funding Information: BJS is supported by NIH grant 1R01CA200808. Funding Information: AAM is supported by NIH grants R01EB016064 and RO1CA172210. OCA is supported by NIH grants R01CA211080 and P50CA165962. WB is supported by the Austrian Science Fund (FWF): KLI‐718, and P30701. AH is supported by European Research Council grant 679927, SYNAPLAST MR, Horizon 2020 project grant 634541, CDS‐QUAMRI and CPRIT Established Researcher Recruitment grant RR180056. SJN is supported by NIH grants R01CA127612, P50CA097257 and P01CA118816. SP is supported by NIH grants 1P30GM122734 and 1R21CA241714. BJS is supported by NIH grant 1R01CA200808. Funding Information: AAM is supported by NIH grants R01EB016064 and RO1CA172210. Funding Information: WB is supported by the Austrian Science Fund (FWF): KLI‐718, and P30701. Funding Information: SP is supported by NIH grants 1P30GM122734 and 1R21CA241714. Funding Information: OCA is supported by NIH grants R01CA211080 and P50CA165962. Funding Information: To the memory of Dr. Sarah Nelson, an esteemed colleague and tireless investigator of MRSI. AAM is supported by NIH grants R01EB016064 and RO1CA172210. OCA is supported by NIH grants R01CA211080 and P50CA165962. WB is supported by the Austrian Science Fund (FWF): KLI-718, and P30701. AH is supported by European Research Council grant 679927, SYNAPLAST MR, Horizon 2020 project grant 634541, CDS-QUAMRI and CPRIT Established Researcher Recruitment grant RR180056. SJN is supported by NIH grants R01CA127612, P50CA097257 and P01CA118816. SP is supported by NIH grants 1P30GM122734 and 1R21CA241714. BJS is supported by NIH grant 1R01CA200808. Funding Information: SJN is supported by NIH grants R01CA127612, P50CA097257 and P01CA118816. Funding Information: AH is supported by European Research Council grant 679927, SYNAPLAST MR, Horizon 2020 project grant 634541, CDS‐QUAMRI and CPRIT Established Researcher Recruitment grant RR180056. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons, Ltd.",
year = "2021",
month = may,
doi = "10.1002/nbm.4309",
language = "English (US)",
volume = "34",
journal = "NMR in Biomedicine",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "5",
}