Advanced minimal residual ovarian carcinoma

Abdominopelvic irradiation following combination chemotherapy

J. D. Hainsworth, A. Malcolm, D. H. Johnson, L. S. Burnett, H. W. Jones, F. A. Greco

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Seventeen patients with advanced ovarian carcinoma who had minimal residual intraabdominal disease after six months of combination chemotherapy were treated with abdominopelvic irradiation. All 17 patients had residual intraabdominal tumor nodules with a cross-sectional diameter of less than 2 cm. Eleven had only microscopic residual disease at the time of irradiation. Fourteen have relapsed at a median of eight months after the completion of radiotherapy. All but two had intraabdominal recurrences. Myelosuppression was common and severe, causing marked delays or discontinuation of radiotherapy in ten of 17 patients. Patients receiving the entire planned dose of radiotherapy had longer disease-free survival (14 months median) than did patients receiving only partial doses (seven months median). However, six of seven patients receiving full dose irradiation have relapsed. Abdominopelvic irradiation in the schedule employed here is poorly tolerated and is not an effective salvage treatment in patients with limited or microscopic residual tumor following initial combination chemotherapy.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalObstetrics and Gynecology
Volume61
Issue number5
StatePublished - 1983

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Combination Drug Therapy
Carcinoma
Residual Neoplasm
Radiotherapy
Salvage Therapy
Disease-Free Survival
Appointments and Schedules
Recurrence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Hainsworth, J. D., Malcolm, A., Johnson, D. H., Burnett, L. S., Jones, H. W., & Greco, F. A. (1983). Advanced minimal residual ovarian carcinoma: Abdominopelvic irradiation following combination chemotherapy. Obstetrics and Gynecology, 61(5), 619-623.

Advanced minimal residual ovarian carcinoma : Abdominopelvic irradiation following combination chemotherapy. / Hainsworth, J. D.; Malcolm, A.; Johnson, D. H.; Burnett, L. S.; Jones, H. W.; Greco, F. A.

In: Obstetrics and Gynecology, Vol. 61, No. 5, 1983, p. 619-623.

Research output: Contribution to journalArticle

Hainsworth, JD, Malcolm, A, Johnson, DH, Burnett, LS, Jones, HW & Greco, FA 1983, 'Advanced minimal residual ovarian carcinoma: Abdominopelvic irradiation following combination chemotherapy', Obstetrics and Gynecology, vol. 61, no. 5, pp. 619-623.
Hainsworth, J. D. ; Malcolm, A. ; Johnson, D. H. ; Burnett, L. S. ; Jones, H. W. ; Greco, F. A. / Advanced minimal residual ovarian carcinoma : Abdominopelvic irradiation following combination chemotherapy. In: Obstetrics and Gynecology. 1983 ; Vol. 61, No. 5. pp. 619-623.
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