Advances in biomarker development in acetaminophen toxicity

Laura P. James, Mitchell R. McGill, Dean W. Roberts, Jack A. Hinson, William M. Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acetaminophen liver injury is the most common cause of acute liver injury in the United States and several other countries. Diagnosis of acetaminophen-induced acute liver injury in the clinic is challenging due to the lack of validated and specific biomarkers. The following chapter provides an overview of recent advances evaluating candidate biomarkers in development for acetaminophen acute liver injury. Relationships of biomarkers to mechanisms of acetaminophen toxicity and their potential role in confirming the diagnosis and/or predicting evolving toxicity are addressed.

Original languageEnglish (US)
Title of host publicationAdvances in Clinical Chemistry
PublisherAcademic Press Inc.
DOIs
StateAccepted/In press - Jan 1 2020

Publication series

NameAdvances in Clinical Chemistry
ISSN (Print)0065-2423
ISSN (Electronic)2162-9471

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Keywords

  • Acetaminophen
  • Biomarker
  • Hepatotoxicity
  • Immunoassay
  • Liver

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

Cite this

James, L. P., McGill, M. R., Roberts, D. W., Hinson, J. A., & Lee, W. M. (Accepted/In press). Advances in biomarker development in acetaminophen toxicity. In Advances in Clinical Chemistry (Advances in Clinical Chemistry). Academic Press Inc.. https://doi.org/10.1016/bs.acc.2020.02.002