Advantages of monodisperse and chemically robust "spherical" polyester dendrimers as a "universal" MS Calibrant

Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalJournal of the American Society for Mass Spectrometry
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 1 2014

    Fingerprint

Keywords

  • Calibrant
  • Calibration
  • Dendrimer
  • MALDI-TOF MS
  • Polymer

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

Cite this