Advantages of monodisperse and chemically robust "spherical" polyester dendrimers as a "universal" MS Calibrant

Scott M. Grayson; Brittany K. Myers; Jonas Bengtsson; Michael Malkoch

doi:10.1007/s13361-013-0777-8

Advantages of monodisperse and chemically robust "spherical" polyester dendrimers as a "universal" MS Calibrant

Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry. [Figure not available: see fulltext.]

Original language	English (US)
Pages (from-to)	303-309
Number of pages	7
Journal	Journal of the American Society for Mass Spectrometry
Volume	25
Issue number	3
DOIs	https://doi.org/10.1007/s13361-013-0777-8
State	Published - Mar 2014

Keywords

Calibrant
Calibration
Dendrimer
MALDI-TOF MS
Polymer

ASJC Scopus subject areas

Structural Biology
Spectroscopy

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10.1007/s13361-013-0777-8

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abstract = "The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry. [Figure not available: see fulltext.]",

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AU - Grayson, Scott M.

AU - Myers, Brittany K.

AU - Bengtsson, Jonas

AU - Malkoch, Michael

PY - 2014/3

Y1 - 2014/3

N2 - The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry. [Figure not available: see fulltext.]

AB - The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry. [Figure not available: see fulltext.]

KW - Calibrant

KW - Calibration

KW - Dendrimer

KW - MALDI-TOF MS

KW - Polymer

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Advantages of monodisperse and chemically robust "spherical" polyester dendrimers as a "universal" MS Calibrant

Abstract

Keywords

ASJC Scopus subject areas

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