Adverse effects of risperidone on eye movement activity: A comparison of risperidone and haloperidol in antipsychotic-naive schizophrenic patients

John A. Sweeney, Kenneth S. Bauer, Matcheri S. Keshavan, Gretchen L. Haas, Nina R. Schooler, Patricia D. Kroboth

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Risperidone is a novel and clinically effective atypical antipsychotic medication with a unique biochemical profile. To contrast the neurophysiological effects of this new medication with those of a typical antipsychotic medication, we performed quantitative measurements of saccadic eye movements in a series of antipsychotic-naive schizophrenic patients treated with either risperidone or haloperidol. Patients were tested before and after 1 month of treatment, and a matched group of healthy subjects was tested twice over a similar time interval. Risperidone, but not haloperidol, was associated with prolonged latency and decreased peak velocity and accuracy of saccadic eye movements that was detectable 4 weeks after treatment initiation. The adverse effects of risperidone may be due to the lack of development of acute tolerance to its powerful serotonergic (5-HT(2A)) antagonism, which could be responsible for the disruption of brainstem physiology in regions controlling saccadic eye movements.

Original languageEnglish (US)
Pages (from-to)217-228
Number of pages12
JournalNeuropsychopharmacology
Volume16
Issue number3
DOIs
StatePublished - Mar 1997

Keywords

  • eye movements
  • haloperidol
  • risperidone
  • saccades
  • side effects

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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