Affinities and intrinsic activities of dopamine receptor agonists for the hD21 and hD4.4 receptors

Robert A. Lahti, Alex Mutin, Erika V. Cochrane, Pieter G. Tepper, Durk Dijkstra, Håkan Wikström, Carol A. Tamminga

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Abstract

The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD21 and hD4.4 receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine hD21 and hD4.4 receptors, respectively. Affinities also varied. A single, or multiple, dopamine D2-type receptor(s) may be involved in schizophrenia and agonists are being tested as therapy. Understanding their properties at the individual dopamine D2-family receptors is important.

Original languageEnglish (US)
JournalEuropean Journal of Pharmacology
Volume301
Issue number1-3
Publication statusPublished - Apr 22 1996

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Keywords

  • Dopamine hD receptor
  • Dopamine hD receptor
  • Intrinsic activity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Lahti, R. A., Mutin, A., Cochrane, E. V., Tepper, P. G., Dijkstra, D., Wikström, H., & Tamminga, C. A. (1996). Affinities and intrinsic activities of dopamine receptor agonists for the hD21 and hD4.4 receptors. European Journal of Pharmacology, 301(1-3).