African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol

Thomas E. Goodwin, Felisia D. Brown, Richard W. Counts, Nichole C. Dowdy, Patrick L. Fraley, Randall A. Hughes, Daniel Z. Liu, Courtney D. Mashburn, Josh D. Rankin, Russell S. Roberson, Katie D. Wooley, Elizabeth L. Rasmussen, Scott W. Riddle, Heidi S. Riddle, Stefan Schulz

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A search for potential semiochemicals revealed nerolidol (6), albicanol (7), and the new 2,3-dihydrofarnesol derivatives 8-10 in the temporal gland secretions of African elephants. A novel synthesis from (E,E)-farnesol (1) provided compounds 8-10 for GC-MS comparison to the natural products. This study confirms the farnesol family as frequently occurring secondary metabolites in African elephant temporal gland secretions.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalJournal of Natural Products
Volume65
Issue number9
DOIs
StatePublished - Sep 1 2002

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Goodwin, T. E., Brown, F. D., Counts, R. W., Dowdy, N. C., Fraley, P. L., Hughes, R. A., Liu, D. Z., Mashburn, C. D., Rankin, J. D., Roberson, R. S., Wooley, K. D., Rasmussen, E. L., Riddle, S. W., Riddle, H. S., & Schulz, S. (2002). African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol. Journal of Natural Products, 65(9), 1319-1322. https://doi.org/10.1021/np010647c