TY - JOUR
T1 - Age
T2 - An effect modifier of the association between allergic rhinitis and Otitis media with effusion
AU - Roditi, Rachel E.
AU - Veling, Maria
AU - Shin, Jennifer J.
N1 - Publisher Copyright:
© 2015 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objectives/Hypothesis: 1) To determine whether there is a significant relationship between allergic rhinitis and otitis media with effusion (OME), Eustachian tube dysfunction (ETD), or tympanic membrane retraction (TMR) in children in a nationally representative population; and 2) to determine whether age is an effect modifier of any such association because this hypothesis has yet to be tested. Study Design: Retrospective analysis of cross-sectional national databases with limited potential for referral bias. Setting and Subjects: National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 2005–2010. Methods: Univariate, multivariate, stratified, and subgroup analyses were performed as defined a priori. The primary outcomes were OME, ETD, or TMR; the primary predictor variable was allergic rhinitis, with age evaluated as an effect modifier. Results: Data representing 1,491,045,375 pediatric visits were examined and demonstrated that age was an effect modifier of the assessed association. More specifically, in children 6 years of age or older, the presence of allergic rhinitis significantly increased the odds of OME, ETD, or TMR (odds ratio [OR] 4.20; 95% confidence interval [CI] 2.17, 8.09; P < 0.001), whereas in children less than 6 years of age there was no significant association (OR 1.13; 95% CI 0.53, 2.46; P = 0.745). Conclusion: Age is an effect modifier of the association between allergic rhinitis and OME; a significant relationship is observed in children 6 years of age and older, whereas there is no significant association in younger children. Level of Evidence: 2c. Laryngoscope, 126:1687–1692, 2016.
AB - Objectives/Hypothesis: 1) To determine whether there is a significant relationship between allergic rhinitis and otitis media with effusion (OME), Eustachian tube dysfunction (ETD), or tympanic membrane retraction (TMR) in children in a nationally representative population; and 2) to determine whether age is an effect modifier of any such association because this hypothesis has yet to be tested. Study Design: Retrospective analysis of cross-sectional national databases with limited potential for referral bias. Setting and Subjects: National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 2005–2010. Methods: Univariate, multivariate, stratified, and subgroup analyses were performed as defined a priori. The primary outcomes were OME, ETD, or TMR; the primary predictor variable was allergic rhinitis, with age evaluated as an effect modifier. Results: Data representing 1,491,045,375 pediatric visits were examined and demonstrated that age was an effect modifier of the assessed association. More specifically, in children 6 years of age or older, the presence of allergic rhinitis significantly increased the odds of OME, ETD, or TMR (odds ratio [OR] 4.20; 95% confidence interval [CI] 2.17, 8.09; P < 0.001), whereas in children less than 6 years of age there was no significant association (OR 1.13; 95% CI 0.53, 2.46; P = 0.745). Conclusion: Age is an effect modifier of the association between allergic rhinitis and OME; a significant relationship is observed in children 6 years of age and older, whereas there is no significant association in younger children. Level of Evidence: 2c. Laryngoscope, 126:1687–1692, 2016.
KW - Otitis media with effusion
KW - age
KW - allergic rhinitis
KW - effect modifier
KW - eustachian tube dysfunction
KW - national database
KW - tympanic membrane retraction
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U2 - 10.1002/lary.25682
DO - 10.1002/lary.25682
M3 - Article
C2 - 26422779
AN - SCOPUS:84975223473
SN - 0023-852X
VL - 126
SP - 1687
EP - 1692
JO - Laryngoscope
JF - Laryngoscope
IS - 7
ER -