Age and motor score predict osteoprotegerin level in chronic spinal cord injury

Leslie R. Morse, H. P. Nguyen, N. Jain, S. Williams, C. G. Tun, R. A. Battaglino, P. Stashenko, E. Garshick

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Objective: Individuals with spinal cord injury (SCI) develop a severe form of osteoporosis below the level of injury that is poorly understood. We conducted a preliminary investigation to assess whether circulating markers of bone turnover and circulating RANKL/OPG levels are related to the severity of SCI, aging, or to differences in mobility (i.e., walking or using a wheelchair). Methods: Sixty-four caucasian men ≥1.6 years since injury selected based on locomotive mode provided blood samples and completed a health questionnaire at the VA Boston Healthcare System from 10/2003 to 6/2005. Plasma sRANKL, osteoprotegerin (OPG), osteocalcin and carboxyterminal telopeptide of type I collagen (CTx) levels were determined. Results: Increasing age was significantly associated with increased OPG and CTx. Injury severity was predictive of OPG levels, and adjusting for age, participants with cervical motor complete and ASIA C SCI (n=11) had significantly lower mean OPG (46.1 pg/ml) levels than others (63.4 pg/ ml). Locomotive mode was not associated with differences in bone markers. Conclusions: Severe cervical spinal cord injury is associated with decreased circulating OPG levels placing these patients at risk for accelerated bone loss that appears unrelated to locomotive mode.

Original languageEnglish (US)
Pages (from-to)50-57
Number of pages8
JournalJournal of Musculoskeletal Neuronal Interactions
Volume8
Issue number1
StatePublished - Mar 1 2008
Externally publishedYes

Keywords

  • Aging
  • Bone
  • Osteoporosis
  • Osteoprotegerin
  • Spinal cord injury

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine

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    Morse, L. R., Nguyen, H. P., Jain, N., Williams, S., Tun, C. G., Battaglino, R. A., Stashenko, P., & Garshick, E. (2008). Age and motor score predict osteoprotegerin level in chronic spinal cord injury. Journal of Musculoskeletal Neuronal Interactions, 8(1), 50-57.