TY - JOUR
T1 - Age-dependent trends in survival after adult in-hospital cardiac arrest
AU - Wiberg, Sebastian
AU - Holmberg, Mathias J.
AU - Donnino, Michael W.
AU - Kjaergaard, Jesper
AU - Hassager, Christian
AU - Witten, Lise
AU - Berg, Katherine M.
AU - Moskowitz, Ari
AU - Andersen, Lars W.
AU - Grossestreuer, Anne
AU - Edelson, Dana
AU - Ornato, Joseph
AU - Peberdy, Mary Ann
AU - Churpek, Matthew
AU - Kurz, Michael
AU - Starks, Monique Anderson
AU - Chan, Paul
AU - Girotra, Saket
AU - Perman, Sarah
AU - Goldberger, Zachary
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/6
Y1 - 2020/6
N2 - Background: While survival after in-hospital cardiac arrest (IHCA) has improved in recent years, it remains unknown whether this trend primarily applies to younger IHCA victims. The aim of this study was to assess trends in survival to hospital discharge after adult IHCA across age groups from 2000 to 2016. Methods: This is an observational study of IHCA patients included in the Get With The Guidelines®-Resuscitation registry between 2000 and 2016. The primary outcome was survival to hospital discharge. Patients were stratified into five age groups: <50 years, 50–59 years, 60–69 years, 70–79 years, and ≥80 years. Generalized linear regression was used to obtain absolute survival rates over time. Results: A total of 234,767 IHCA patients were included. The absolute increase in survival per calendar year was 0.8% (95% CI 0.7–1.0%, p < 0.001) for patients younger than 50 years, 0.6% (95% CI 0.4–0.7%, p < 0.001) for patients between 50 and 59 years, 0.5% (95% CI 0.4–0.6%, p < 0.001) for patients between 60 and 69 years, 0.5% (95% CI 0.4–0.6%, p < 0.001) for patients between 70 and 79 years, and 0.5% (95% CI 0.4–0.6%, p < 0.001) for patients older than 80 years. We observed a significant interaction between calendar year and age group (p < 0.001), indicating that the rate of improvement in survival over time was significantly different between age groups. Conclusions: For patients with IHCA, rates of survival to discharge have improved significantly from 2000 to 2016 across all age groups.
AB - Background: While survival after in-hospital cardiac arrest (IHCA) has improved in recent years, it remains unknown whether this trend primarily applies to younger IHCA victims. The aim of this study was to assess trends in survival to hospital discharge after adult IHCA across age groups from 2000 to 2016. Methods: This is an observational study of IHCA patients included in the Get With The Guidelines®-Resuscitation registry between 2000 and 2016. The primary outcome was survival to hospital discharge. Patients were stratified into five age groups: <50 years, 50–59 years, 60–69 years, 70–79 years, and ≥80 years. Generalized linear regression was used to obtain absolute survival rates over time. Results: A total of 234,767 IHCA patients were included. The absolute increase in survival per calendar year was 0.8% (95% CI 0.7–1.0%, p < 0.001) for patients younger than 50 years, 0.6% (95% CI 0.4–0.7%, p < 0.001) for patients between 50 and 59 years, 0.5% (95% CI 0.4–0.6%, p < 0.001) for patients between 60 and 69 years, 0.5% (95% CI 0.4–0.6%, p < 0.001) for patients between 70 and 79 years, and 0.5% (95% CI 0.4–0.6%, p < 0.001) for patients older than 80 years. We observed a significant interaction between calendar year and age group (p < 0.001), indicating that the rate of improvement in survival over time was significantly different between age groups. Conclusions: For patients with IHCA, rates of survival to discharge have improved significantly from 2000 to 2016 across all age groups.
KW - Age
KW - In-hospital cardiac arrest
KW - Survival
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U2 - 10.1016/j.resuscitation.2020.03.008
DO - 10.1016/j.resuscitation.2020.03.008
M3 - Article
C2 - 32246986
AN - SCOPUS:85084232023
SN - 0300-9572
VL - 151
SP - 189
EP - 196
JO - Resuscitation
JF - Resuscitation
ER -