Aggregation-induced near-infrared absorption of squaraine dye in an albumin nanocomplex for photoacoustic tomography in vivo

Fei Fei An, Zi Jian Deng, Jun Ye, Jin Feng Zhang, Yin Long Yang, Chang Hui Li, Cai Jun Zheng, Xiao Hong Zhang

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Photoacoustic tomography (PAT) is a newly emerging noninvasive imaging modality that could be further enhanced using near-infrared (NIR)-absorbing materials as contrast agents. To date, the most extensively studied photoacoustic imaging agents are inorganic nanomaterials because organic materials with NIR-absorption capabilities are limited. In this study, a NIR-absorbing nanocomplex composed of a squaraine dye (SQ) and albumin was prepared based on the aggregation-induced NIR absorption of SQ. Through aggregation, the absorption spectrum of SQ was widened from the visible-light region to the NIR region, which facilitated photoacoustic signal generation in the tissue-transparent NIR optical window (700-900 nm). Blood analysis and histology measurements revealed that the nanocomplex can be used for PAT applications in vivo without obvious toxicity to living mice.

Original languageEnglish (US)
Pages (from-to)17985-17992
Number of pages8
JournalACS Applied Materials and Interfaces
Volume6
Issue number20
DOIs
StatePublished - Oct 22 2014
Externally publishedYes

Keywords

  • albumin
  • nanocomplex
  • near-infrared
  • photoacoustic tomography
  • red shift
  • squaraine dye

ASJC Scopus subject areas

  • Materials Science(all)

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