Aging: A shift from redox regulation to oxidative damage

Kenneth M. Humphries, Pamela A. Szweda, Luke I. Szweda

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Proteins, nucleic acids, and lipids can undergo various forms of oxidative modification. In numerous instances, these modifications result in irreversible loss of function. The age-dependent accumulation of oxidatively modified and dysfunctional macromolecules provides the basis for the free radical theory of aging. Pro-oxidants, however, are also capable of catalyzing fully reversible modifications to protein. It is increasingly apparent that these reactions participate in redox-dependent regulation of cell metabolism and response to stress. The adventitious use of free radical species adds complexity to the experimental and theoretical manner in which the free radical theory is to be tested and considered. Elucidation of mechanisms by which reversible oxidative processes are controlled, the components involved, and the metabolic consequences and how they are altered with age will provide new insight on the aging process and attempts to delay the inevitable.

Original languageEnglish (US)
Pages (from-to)1239-1243
Number of pages5
JournalFree Radical Research
Volume40
Issue number12
DOIs
StatePublished - Dec 1 2006

Keywords

  • Aging
  • Free radicals
  • Mitochondria
  • Oxidative damage
  • Redox Regulation

ASJC Scopus subject areas

  • Biochemistry

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