Aging changes in lumbar discs and vertebrae and their interaction: A 15-year follow-up study

Tapio Videman, Michele C. Battié, Laura E. Gibbons, Kevin Gill

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background context Many studies have focused on either the intervertebral disc as a culprit in back pain problems, or the vertebral body, but very few studies have examined both structures and their relationship. Purpose To measure the concordant changes in morphology of the discs and vertebrae during 5-, 10-, and 15-year follow-ups. Study design Longitudinal study. Patient sample Among a general population sample of 232 men that had been scanned in 1992-1993, 105 men were reexamined in 1997-1998 and 2007-2008. Mean age at the 15-year follow-up was 63 years. A confirmatory sample with 10 years follow-up was also included. Methods Scanners (1.5 Tesla) with surface coils were used at baseline and follow-up. Image analyzing software was used to measure distances and areas of interest of midsagittal and midaxial spine images. Results The disc heights decreased at 5 years by 3.4% (0.4 mm) and 3.3% (0.4 mm) and at 15 years by 8.7% (1.0 mm) and 11.3% (1.3 mm) in the upper and lower discs, respectively (p<.001). Although not clear after 5 years, vertebra heights increased in mean by 3.1% (0.8 mm) in the upper lumbar levels and by 4.7% (1.1 mm) in the lower vertebrae after 15 years (p<.001). Vertebra height increases were associated with disc narrowing (p=.001). The mean annual shortening of the lumbar spine L1-S1 block was 0.13 mm/y, which was in line with the mean standing height that decreased little (174.7 cm at baseline and 174.4 cm at the follow-up). Conclusions Discs and vertebrae degenerate or remodel in concert: decreases in disc height appear to be compensated, in part, by accompanying increases in adjacent vertebra heights. The mechanism behind this novel finding and its implications require further study.

Original languageEnglish (US)
Pages (from-to)469-478
Number of pages10
JournalSpine Journal
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2014

Fingerprint

Lumbar Vertebrae
Spine
Intervertebral Disc
Back Pain
Longitudinal Studies
Software

Keywords

  • Disc degeneration
  • End plate
  • Lumbar spine
  • MRI
  • Pathology
  • Vertebra

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Aging changes in lumbar discs and vertebrae and their interaction : A 15-year follow-up study. / Videman, Tapio; Battié, Michele C.; Gibbons, Laura E.; Gill, Kevin.

In: Spine Journal, Vol. 14, No. 3, 01.03.2014, p. 469-478.

Research output: Contribution to journalArticle

Videman, Tapio ; Battié, Michele C. ; Gibbons, Laura E. ; Gill, Kevin. / Aging changes in lumbar discs and vertebrae and their interaction : A 15-year follow-up study. In: Spine Journal. 2014 ; Vol. 14, No. 3. pp. 469-478.
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title = "Aging changes in lumbar discs and vertebrae and their interaction: A 15-year follow-up study",
abstract = "Background context Many studies have focused on either the intervertebral disc as a culprit in back pain problems, or the vertebral body, but very few studies have examined both structures and their relationship. Purpose To measure the concordant changes in morphology of the discs and vertebrae during 5-, 10-, and 15-year follow-ups. Study design Longitudinal study. Patient sample Among a general population sample of 232 men that had been scanned in 1992-1993, 105 men were reexamined in 1997-1998 and 2007-2008. Mean age at the 15-year follow-up was 63 years. A confirmatory sample with 10 years follow-up was also included. Methods Scanners (1.5 Tesla) with surface coils were used at baseline and follow-up. Image analyzing software was used to measure distances and areas of interest of midsagittal and midaxial spine images. Results The disc heights decreased at 5 years by 3.4{\%} (0.4 mm) and 3.3{\%} (0.4 mm) and at 15 years by 8.7{\%} (1.0 mm) and 11.3{\%} (1.3 mm) in the upper and lower discs, respectively (p<.001). Although not clear after 5 years, vertebra heights increased in mean by 3.1{\%} (0.8 mm) in the upper lumbar levels and by 4.7{\%} (1.1 mm) in the lower vertebrae after 15 years (p<.001). Vertebra height increases were associated with disc narrowing (p=.001). The mean annual shortening of the lumbar spine L1-S1 block was 0.13 mm/y, which was in line with the mean standing height that decreased little (174.7 cm at baseline and 174.4 cm at the follow-up). Conclusions Discs and vertebrae degenerate or remodel in concert: decreases in disc height appear to be compensated, in part, by accompanying increases in adjacent vertebra heights. The mechanism behind this novel finding and its implications require further study.",
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AB - Background context Many studies have focused on either the intervertebral disc as a culprit in back pain problems, or the vertebral body, but very few studies have examined both structures and their relationship. Purpose To measure the concordant changes in morphology of the discs and vertebrae during 5-, 10-, and 15-year follow-ups. Study design Longitudinal study. Patient sample Among a general population sample of 232 men that had been scanned in 1992-1993, 105 men were reexamined in 1997-1998 and 2007-2008. Mean age at the 15-year follow-up was 63 years. A confirmatory sample with 10 years follow-up was also included. Methods Scanners (1.5 Tesla) with surface coils were used at baseline and follow-up. Image analyzing software was used to measure distances and areas of interest of midsagittal and midaxial spine images. Results The disc heights decreased at 5 years by 3.4% (0.4 mm) and 3.3% (0.4 mm) and at 15 years by 8.7% (1.0 mm) and 11.3% (1.3 mm) in the upper and lower discs, respectively (p<.001). Although not clear after 5 years, vertebra heights increased in mean by 3.1% (0.8 mm) in the upper lumbar levels and by 4.7% (1.1 mm) in the lower vertebrae after 15 years (p<.001). Vertebra height increases were associated with disc narrowing (p=.001). The mean annual shortening of the lumbar spine L1-S1 block was 0.13 mm/y, which was in line with the mean standing height that decreased little (174.7 cm at baseline and 174.4 cm at the follow-up). Conclusions Discs and vertebrae degenerate or remodel in concert: decreases in disc height appear to be compensated, in part, by accompanying increases in adjacent vertebra heights. The mechanism behind this novel finding and its implications require further study.

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KW - End plate

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KW - Pathology

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