TY - JOUR
T1 - Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
AU - Hasegawa, Daisuke
AU - Hori, Amane
AU - Okamura, Yukiko
AU - Baba, Reizo
AU - Suijo, Kenichi
AU - Mizuno, Masaki
AU - Sugawara, Jun
AU - Kitatsuji, Koji
AU - Ogata, Hisayoshi
AU - Toda, Kaoru
AU - Hotta, Norio
N1 - Funding Information:
This work was supported in part by JSPS KAKENHI JP17K01769 (N.H.), the Health Science Center Foundation (N.H.), the Short‐term Research Project from the Research Institute of Life and Health Sciences of Chubu University (N.H.), and the Nakatomi Foundation (N.H.).
Publisher Copyright:
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
PY - 2021/11
Y1 - 2021/11
N2 - Ischemic skeletal muscle conditions are known to augment exercise-induced increases in blood pressure (BP). Aging is also a factor that enhances the pressor response to exercise. However, the effects of aging on the BP response to ischemic exercise remain unclear. We, therefore, tested the hypothesis that aging enhances the BP response to rhythmic handgrip (RHG) exercise during postexercise muscle ischemia (PEMI). We divided the normotensive participants without cardiovascular diseases into three age groups: young (n = 26; age, 18–28 years), middle-aged (n = 23; age, 35–59 years), and older adults (n = 23; age, 60–80 years). The participants performed RHG exercise with minimal effort for 1 min after rest with and without PEMI, which was induced by inflating a cuff on the upper arm just before the isometric handgrip exercise ended; the intensity was 30% of maximal voluntary contraction force. Under PEMI, the increase in diastolic BP (DBP) from rest to RHG exercise in the older adult group (Δ13 ± 2 mmHg) was significantly higher than that in the young (Δ5 ± 2 mmHg) and middle-aged groups (Δ6 ± 1 mmHg), despite there being no significant difference between the groups in the DBP response from rest to RHG exercise without PEMI. Importantly, based on multiple regression analysis, age remained a significant independent determinant of both the SBP and DBP responses to RHG exercise during PEMI (p < 0.01). These findings indicate that aging enhances the pressor response to ischemic rhythmic exercise.
AB - Ischemic skeletal muscle conditions are known to augment exercise-induced increases in blood pressure (BP). Aging is also a factor that enhances the pressor response to exercise. However, the effects of aging on the BP response to ischemic exercise remain unclear. We, therefore, tested the hypothesis that aging enhances the BP response to rhythmic handgrip (RHG) exercise during postexercise muscle ischemia (PEMI). We divided the normotensive participants without cardiovascular diseases into three age groups: young (n = 26; age, 18–28 years), middle-aged (n = 23; age, 35–59 years), and older adults (n = 23; age, 60–80 years). The participants performed RHG exercise with minimal effort for 1 min after rest with and without PEMI, which was induced by inflating a cuff on the upper arm just before the isometric handgrip exercise ended; the intensity was 30% of maximal voluntary contraction force. Under PEMI, the increase in diastolic BP (DBP) from rest to RHG exercise in the older adult group (Δ13 ± 2 mmHg) was significantly higher than that in the young (Δ5 ± 2 mmHg) and middle-aged groups (Δ6 ± 1 mmHg), despite there being no significant difference between the groups in the DBP response from rest to RHG exercise without PEMI. Importantly, based on multiple regression analysis, age remained a significant independent determinant of both the SBP and DBP responses to RHG exercise during PEMI (p < 0.01). These findings indicate that aging enhances the pressor response to ischemic rhythmic exercise.
KW - acidosis
KW - exercise pressor reflex
KW - muscle mechanoreflex
KW - muscle metaboreflex
KW - postexercise muscle ischemia
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U2 - 10.14814/phy2.15125
DO - 10.14814/phy2.15125
M3 - Article
C2 - 34817113
AN - SCOPUS:85119988263
SN - 2051-817X
VL - 9
JO - Physiological Reports
JF - Physiological Reports
IS - 22
M1 - e15125
ER -