Aging is not associated with bone marrow-resident progenitor cell depletion

Thomas J. Povsic, Jiying Zhou, Stacie D. Adams, Michael P. Bolognesi, David E. Attarian, Eric D. Peterson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Changes in progenitor cell biology remain at the forefront of many theories of biologic aging, but there are limited studies evaluating this in humans. Aging has been associated with a progressive depletion of circulating progenitor cells, but age-related bone marrow-resident progenitor cell depletion has not been systematically determined in humans. Patients undergoing total hip replacement were consented, and bone marrow and peripheral progenitor cells were enumerated based on aldehyde dehydrogenase activity and CD34 and CD133 expression. Circulating progenitors demonstrated an age-dependent decline. In contrast, marrow-resident progenitor cell content demonstrated no age association with any progenitor cell subtype. In humans, aging is associated with depletion of circulating, but not marrow-resident, progenitors. This finding has impact on the mechanism(s) responsible for age-related changes in circulating stem cells and important implications for the use of autologous marrow for the treatment of age-related diseases.

Original languageEnglish (US)
Pages (from-to)1042-1050
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume65 A
Issue number10
StatePublished - Oct 2010
Externally publishedYes


  • Aging
  • Bone marrow
  • Circulating progenitor cell
  • Endothelial progenitor cells
  • Progenitor cell

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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