AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs

Margaret V. Ragni; Steven H. Belle; Ronald Jaffe; Joseph Locker; Sandra L. Duerstein; Debra C. Bass; Joseph E. Addiego; Louis M. Aledort; Lloyd E. Barron; Doreen B. Brettler; George R. Buchanan; Joan C. Gill; Bruce M. Ewenstein; David Green; Margaret W. Hilgartner; W. Keith Hoots; C. Thomas Kisker; Everett W. Lovrien; Cynthia J. Rutherford; Natalie L. Sanders; Kenneth J. Smith; Sally P. Stabler; Susan Swindells; Gilbert C. White; Lawrence A. Kingsley

doi:10.1097/00042560-199609000-00011

AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs

Margaret V. Ragni, Steven H. Belle, Ronald Jaffe, Joseph Locker, Sandra L. Duerstein, Debra C. Bass, Joseph E. Addiego, Louis M. Aledort, Lloyd E. Barron, Doreen B. Brettler, George R. Buchanan, Joan C. Gill, Bruce M. Ewenstein, David Green, Margaret W. Hilgartner, W. Keith Hoots, C. Thomas Kisker, Everett W. Lovrien, Cynthia J. Rutherford, Natalie L. SandersKenneth J. Smith, Sally P. Stabler, Susan Swindells, Gilbert C. White, Lawrence A. Kingsley

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We studied the characteristics and temporal trends of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) in individuals with hemophilia. Prospective data were collected on 33 HIV-positive hemophiliacs with AIDS-NHL enrolled in the Hemophilia Malignancy Study (HMS), of whom 21 had primary and 12 had secondary or subsequent AIDS-defining illnesses, and analyzed for frequency and temporal trends. As compared with primary AIDS-NHL, secondary AIDS-NHL occurred at an older mean age, 37 versus 29 years (p =0.12); at a lower mean CD4 count, 46 versus 154 (p = 0.07); after a longer period of immunosuppression (CD4 < 200/μl), 41 versus 16 months (p = 0.03); and with shorter median survival, 2 versus 7 months (p = 0.09). The presence of EBV in tumor tissue was associated with shorter survival, 1 versus 7 months (p = 0.17). Between 1981 and 1988 and 1989 and 1994, the proportion of primary AIDS diagnoses that were AIDS-NHL changed minimally, 4.6 versus 6.1%, whereas there were significant decreases in Pneumocystis carinii pneumonia (PCP, p = 0.02) and wasting (p = 0.07), and an increase in Candida (p = 0.004). These findings confirm that an increasing proportion of AIDS-NHL in hemophiliacs are occurring as secondary or later AIDS diagnoses, and they are associated with prolonged duration of immunosuppression.

Original language	English (US)
Pages (from-to)	78-86
Number of pages	9
Journal	Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1097/00042560-199609000-00011
State	Published - 1996

Keywords

AIDS
Hemophilia
Non-Hodgkin's lymphoma

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Virology

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10.1097/00042560-199609000-00011

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Ragni, M. V., Belle, S. H., Jaffe, R., Locker, J., Duerstein, S. L., Bass, D. C., Addiego, J. E., Aledort, L. M., Barron, L. E., Brettler, D. B., Buchanan, G. R., Gill, J. C., Ewenstein, B. M., Green, D., Hilgartner, M. W., Hoots, W. K., Kisker, C. T., Lovrien, E. W., Rutherford, C. J., ... Kingsley, L. A. (1996). AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 13(1), 78-86. https://doi.org/10.1097/00042560-199609000-00011

Ragni, MV, Belle, SH, Jaffe, R, Locker, J, Duerstein, SL, Bass, DC, Addiego, JE, Aledort, LM, Barron, LE, Brettler, DB, Buchanan, GR, Gill, JC, Ewenstein, BM, Green, D, Hilgartner, MW, Hoots, WK, Kisker, CT, Lovrien, EW, Rutherford, CJ, Sanders, NL, Smith, KJ, Stabler, SP, Swindells, S, White, GC & Kingsley, LA 1996, 'AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 13, no. 1, pp. 78-86. https://doi.org/10.1097/00042560-199609000-00011

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title = "AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs",

abstract = "We studied the characteristics and temporal trends of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) in individuals with hemophilia. Prospective data were collected on 33 HIV-positive hemophiliacs with AIDS-NHL enrolled in the Hemophilia Malignancy Study (HMS), of whom 21 had primary and 12 had secondary or subsequent AIDS-defining illnesses, and analyzed for frequency and temporal trends. As compared with primary AIDS-NHL, secondary AIDS-NHL occurred at an older mean age, 37 versus 29 years (p =0.12); at a lower mean CD4 count, 46 versus 154 (p = 0.07); after a longer period of immunosuppression (CD4 < 200/μl), 41 versus 16 months (p = 0.03); and with shorter median survival, 2 versus 7 months (p = 0.09). The presence of EBV in tumor tissue was associated with shorter survival, 1 versus 7 months (p = 0.17). Between 1981 and 1988 and 1989 and 1994, the proportion of primary AIDS diagnoses that were AIDS-NHL changed minimally, 4.6 versus 6.1%, whereas there were significant decreases in Pneumocystis carinii pneumonia (PCP, p = 0.02) and wasting (p = 0.07), and an increase in Candida (p = 0.004). These findings confirm that an increasing proportion of AIDS-NHL in hemophiliacs are occurring as secondary or later AIDS diagnoses, and they are associated with prolonged duration of immunosuppression.",

keywords = "AIDS, Hemophilia, Non-Hodgkin's lymphoma",

author = "Ragni, {Margaret V.} and Belle, {Steven H.} and Ronald Jaffe and Joseph Locker and Duerstein, {Sandra L.} and Bass, {Debra C.} and Addiego, {Joseph E.} and Aledort, {Louis M.} and Barron, {Lloyd E.} and Brettler, {Doreen B.} and Buchanan, {George R.} and Gill, {Joan C.} and Ewenstein, {Bruce M.} and David Green and Hilgartner, {Margaret W.} and Hoots, {W. Keith} and Kisker, {C. Thomas} and Lovrien, {Everett W.} and Rutherford, {Cynthia J.} and Sanders, {Natalie L.} and Smith, {Kenneth J.} and Stabler, {Sally P.} and Susan Swindells and White, {Gilbert C.} and Kingsley, {Lawrence A.}",

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doi = "10.1097/00042560-199609000-00011",

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pages = "78--86",

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T1 - AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs

AU - Ragni, Margaret V.

AU - Belle, Steven H.

AU - Jaffe, Ronald

AU - Locker, Joseph

AU - Duerstein, Sandra L.

AU - Bass, Debra C.

AU - Addiego, Joseph E.

AU - Aledort, Louis M.

AU - Barron, Lloyd E.

AU - Brettler, Doreen B.

AU - Buchanan, George R.

AU - Gill, Joan C.

AU - Ewenstein, Bruce M.

AU - Green, David

AU - Hilgartner, Margaret W.

AU - Hoots, W. Keith

AU - Kisker, C. Thomas

AU - Lovrien, Everett W.

AU - Rutherford, Cynthia J.

AU - Sanders, Natalie L.

AU - Smith, Kenneth J.

AU - Stabler, Sally P.

AU - Swindells, Susan

AU - White, Gilbert C.

AU - Kingsley, Lawrence A.

PY - 1996

Y1 - 1996

N2 - We studied the characteristics and temporal trends of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) in individuals with hemophilia. Prospective data were collected on 33 HIV-positive hemophiliacs with AIDS-NHL enrolled in the Hemophilia Malignancy Study (HMS), of whom 21 had primary and 12 had secondary or subsequent AIDS-defining illnesses, and analyzed for frequency and temporal trends. As compared with primary AIDS-NHL, secondary AIDS-NHL occurred at an older mean age, 37 versus 29 years (p =0.12); at a lower mean CD4 count, 46 versus 154 (p = 0.07); after a longer period of immunosuppression (CD4 < 200/μl), 41 versus 16 months (p = 0.03); and with shorter median survival, 2 versus 7 months (p = 0.09). The presence of EBV in tumor tissue was associated with shorter survival, 1 versus 7 months (p = 0.17). Between 1981 and 1988 and 1989 and 1994, the proportion of primary AIDS diagnoses that were AIDS-NHL changed minimally, 4.6 versus 6.1%, whereas there were significant decreases in Pneumocystis carinii pneumonia (PCP, p = 0.02) and wasting (p = 0.07), and an increase in Candida (p = 0.004). These findings confirm that an increasing proportion of AIDS-NHL in hemophiliacs are occurring as secondary or later AIDS diagnoses, and they are associated with prolonged duration of immunosuppression.

AB - We studied the characteristics and temporal trends of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) in individuals with hemophilia. Prospective data were collected on 33 HIV-positive hemophiliacs with AIDS-NHL enrolled in the Hemophilia Malignancy Study (HMS), of whom 21 had primary and 12 had secondary or subsequent AIDS-defining illnesses, and analyzed for frequency and temporal trends. As compared with primary AIDS-NHL, secondary AIDS-NHL occurred at an older mean age, 37 versus 29 years (p =0.12); at a lower mean CD4 count, 46 versus 154 (p = 0.07); after a longer period of immunosuppression (CD4 < 200/μl), 41 versus 16 months (p = 0.03); and with shorter median survival, 2 versus 7 months (p = 0.09). The presence of EBV in tumor tissue was associated with shorter survival, 1 versus 7 months (p = 0.17). Between 1981 and 1988 and 1989 and 1994, the proportion of primary AIDS diagnoses that were AIDS-NHL changed minimally, 4.6 versus 6.1%, whereas there were significant decreases in Pneumocystis carinii pneumonia (PCP, p = 0.02) and wasting (p = 0.07), and an increase in Candida (p = 0.004). These findings confirm that an increasing proportion of AIDS-NHL in hemophiliacs are occurring as secondary or later AIDS diagnoses, and they are associated with prolonged duration of immunosuppression.

KW - AIDS

KW - Hemophilia

KW - Non-Hodgkin's lymphoma

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ER -

AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs

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Keywords

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