Aiolos and Lymphocyte Mimicry in Lung Cancer

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.

Original languageEnglish (US)
Article numbere29912
JournalMolecular and Cellular Oncology
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Aiolos
  • anchorage independence
  • anoikis
  • Ikaros
  • IKZF3
  • lung cancer
  • lymphocyte
  • p66Shc
  • Shc

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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