Aiolos and Lymphocyte Mimicry in Lung Cancer

Lance S. Terada; Zhe Liu

doi:10.4161/mco.29912

Aiolos and Lymphocyte Mimicry in Lung Cancer

Lance S. Terada, Zhe Liu

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.

Original language	English (US)
Article number	e29912
Journal	Molecular and Cellular Oncology
Volume	1
Issue number	1
DOIs	https://doi.org/10.4161/mco.29912
State	Published - Jan 1 2014

Keywords

Aiolos
IKZF3
Ikaros
Shc
anchorage independence
anoikis
lung cancer
lymphocyte
p66Shc

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/mco.29912

Cite this

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title = "Aiolos and Lymphocyte Mimicry in Lung Cancer",

abstract = "Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.",

keywords = "Aiolos, IKZF3, Ikaros, Shc, anchorage independence, anoikis, lung cancer, lymphocyte, p66Shc",

author = "Terada, {Lance S.} and Zhe Liu",

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T1 - Aiolos and Lymphocyte Mimicry in Lung Cancer

AU - Terada, Lance S.

AU - Liu, Zhe

N1 - Funding Information: The authors were supported by the American Heart Association, the National Institutes of Health, the Ministry of Science and Technology of China, the National Natural Science Foundation of China, the Tianjin Municipal Science and Technology Commission, the specialized Fund for the Doctoral Program of Higher Education, and the China Postdoctoral Science Foundation. Publisher Copyright: © 2014, Copyright © 2014 Landes Bioscience.

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N2 - Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.

AB - Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.

KW - Aiolos

KW - IKZF3

KW - Ikaros

KW - Shc

KW - anchorage independence

KW - anoikis

KW - lung cancer

KW - lymphocyte

KW - p66Shc

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M3 - Review article

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JF - Molecular and Cellular Oncology

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ER -

Aiolos and Lymphocyte Mimicry in Lung Cancer

Abstract

Keywords

ASJC Scopus subject areas

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