Aiolos and Lymphocyte Mimicry in Lung Cancer

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Abstract

Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.

Original languageEnglish (US)
Article numbere29912
JournalMolecular and Cellular Oncology
Volume1
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Aiolos
  • anchorage independence
  • anoikis
  • Ikaros
  • IKZF3
  • lung cancer
  • lymphocyte
  • p66Shc
  • Shc

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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