Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts

James M. Brown, Connie J. Beehler, Elaine M. Berger, Michael A. Grosso, Glenn J. Whitman, Lance S. Terada, John A. Leff, Alden H. Harken, John E. Repine

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22 Scopus citations

Abstract

Perfusion with human serum albumin decreased myocardial hydrogen peroxide (H2O2) levels (as assessed by inactivation of myocardial catalase activities following ammotriazole pretreatment) and increased myocardial ventricular developed pressures (DP), contractility (+dP/dt) but not relaxation rate (-dP/dt) in isolated crystalloid perfused rat hearts subjected to normothermic global ischemia (20 min) and then reperfusion (40 min). Albumin also decreased H2O2 concentrations in vitro. The findings support the possibility that albumin may act as a protective O2 metabolite scavenger in vivo.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalInflammation
Volume13
Issue number5
DOIs
StatePublished - Oct 1 1989

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Brown, J. M., Beehler, C. J., Berger, E. M., Grosso, M. A., Whitman, G. J., Terada, L. S., Leff, J. A., Harken, A. H., & Repine, J. E. (1989). Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts. Inflammation, 13(5), 583-589. https://doi.org/10.1007/BF00916764