Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts

James M. Brown; Connie J. Beehler; Elaine M. Berger; Michael A. Grosso; Glenn J. Whitman; Lance S. Terada; John A. Leff; Alden H. Harken; John E. Repine

doi:10.1007/BF00916764

Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts

James M. Brown, Connie J. Beehler, Elaine M. Berger, Michael A. Grosso, Glenn J. Whitman, Lance S. Terada, John A. Leff, Alden H. Harken, John E. Repine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Perfusion with human serum albumin decreased myocardial hydrogen peroxide (H₂O₂) levels (as assessed by inactivation of myocardial catalase activities following ammotriazole pretreatment) and increased myocardial ventricular developed pressures (DP), contractility (+dP/dt) but not relaxation rate (-dP/dt) in isolated crystalloid perfused rat hearts subjected to normothermic global ischemia (20 min) and then reperfusion (40 min). Albumin also decreased H₂O₂ concentrations in vitro. The findings support the possibility that albumin may act as a protective O₂ metabolite scavenger in vivo.

Original language	English (US)
Pages (from-to)	583-589
Number of pages	7
Journal	Inflammation
Volume	13
Issue number	5
DOIs	https://doi.org/10.1007/BF00916764
State	Published - Oct 1989

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts",

abstract = "Perfusion with human serum albumin decreased myocardial hydrogen peroxide (H2O2) levels (as assessed by inactivation of myocardial catalase activities following ammotriazole pretreatment) and increased myocardial ventricular developed pressures (DP), contractility (+dP/dt) but not relaxation rate (-dP/dt) in isolated crystalloid perfused rat hearts subjected to normothermic global ischemia (20 min) and then reperfusion (40 min). Albumin also decreased H2O2 concentrations in vitro. The findings support the possibility that albumin may act as a protective O2 metabolite scavenger in vivo.",

author = "Brown, {James M.} and Beehler, {Connie J.} and Berger, {Elaine M.} and Grosso, {Michael A.} and Whitman, {Glenn J.} and Terada, {Lance S.} and Leff, {John A.} and Harken, {Alden H.} and Repine, {John E.}",

year = "1989",

month = oct,

doi = "10.1007/BF00916764",

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T1 - Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts

AU - Brown, James M.

AU - Beehler, Connie J.

AU - Berger, Elaine M.

AU - Grosso, Michael A.

AU - Whitman, Glenn J.

AU - Terada, Lance S.

AU - Leff, John A.

AU - Harken, Alden H.

AU - Repine, John E.

PY - 1989/10

Y1 - 1989/10

N2 - Perfusion with human serum albumin decreased myocardial hydrogen peroxide (H2O2) levels (as assessed by inactivation of myocardial catalase activities following ammotriazole pretreatment) and increased myocardial ventricular developed pressures (DP), contractility (+dP/dt) but not relaxation rate (-dP/dt) in isolated crystalloid perfused rat hearts subjected to normothermic global ischemia (20 min) and then reperfusion (40 min). Albumin also decreased H2O2 concentrations in vitro. The findings support the possibility that albumin may act as a protective O2 metabolite scavenger in vivo.

AB - Perfusion with human serum albumin decreased myocardial hydrogen peroxide (H2O2) levels (as assessed by inactivation of myocardial catalase activities following ammotriazole pretreatment) and increased myocardial ventricular developed pressures (DP), contractility (+dP/dt) but not relaxation rate (-dP/dt) in isolated crystalloid perfused rat hearts subjected to normothermic global ischemia (20 min) and then reperfusion (40 min). Albumin also decreased H2O2 concentrations in vitro. The findings support the possibility that albumin may act as a protective O2 metabolite scavenger in vivo.

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Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts

Abstract

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