ALBUMIN RETENTION OF C//1//8 ALKYLATED BIOMER VASCULAR GRAFTS.

R. C. Eberhart, M. S. Munro, G. O. Bridges, P. V. Kulkarni, W. J. Fry

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

One of the most demanding tests of thromboresistance occurs in studies of implanted small vessel grafts. In such applications microthrombi form and embolize, even when most stringent protective measures are employed. A method which may improve the thromboresistance of such grafts is to provide a dynamically renewable, endogenous albumin coat between the surface of the device and the blood. The albumin layer serves to mask the substrate from blood-borne host defense activation mechanisms. We have developed an alkylation process which takes advantage of the high affinity of serum albumin for 16 and 18 carbon aliphatic chains.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
EditorsJames M. Anderson
Place of PublicationSan Antonio, TX, USA
PublisherSoc for Biomaterials
Pages97
Number of pages1
Volume7
StatePublished - 1984

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'ALBUMIN RETENTION OF C//1//8 ALKYLATED BIOMER VASCULAR GRAFTS.'. Together they form a unique fingerprint.

Cite this