ALBUMIN RETENTION OF C//1//8 ALKYLATED BIOMER VASCULAR GRAFTS.

R. C. Eberhart; M. S. Munro; G. O. Bridges; P. V. Kulkarni; W. J. Fry

ALBUMIN RETENTION OF C//1//8 ALKYLATED BIOMER VASCULAR GRAFTS.

R. C. Eberhart, M. S. Munro, G. O. Bridges, P. V. Kulkarni, W. J. Fry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

One of the most demanding tests of thromboresistance occurs in studies of implanted small vessel grafts. In such applications microthrombi form and embolize, even when most stringent protective measures are employed. A method which may improve the thromboresistance of such grafts is to provide a dynamically renewable, endogenous albumin coat between the surface of the device and the blood. The albumin layer serves to mask the substrate from blood-borne host defense activation mechanisms. We have developed an alkylation process which takes advantage of the high affinity of serum albumin for 16 and 18 carbon aliphatic chains.

Original language	English (US)
Title of host publication	Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors	James M. Anderson
Place of Publication	San Antonio, TX, USA
Publisher	Soc for Biomaterials
Pages	97
Number of pages	1
Volume	7
State	Published - 1984

ASJC Scopus subject areas

General Materials Science

Cite this

ALBUMIN RETENTION OF C//1//8 ALKYLATED BIOMER VASCULAR GRAFTS. / Eberhart, R. C.; Munro, M. S.; Bridges, G. O. et al.
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / James M. Anderson. Vol. 7 San Antonio, TX, USA: Soc for Biomaterials, 1984. p. 97.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Kulkarni, P. V.

AU - Fry, W. J.

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AB - One of the most demanding tests of thromboresistance occurs in studies of implanted small vessel grafts. In such applications microthrombi form and embolize, even when most stringent protective measures are employed. A method which may improve the thromboresistance of such grafts is to provide a dynamically renewable, endogenous albumin coat between the surface of the device and the blood. The albumin layer serves to mask the substrate from blood-borne host defense activation mechanisms. We have developed an alkylation process which takes advantage of the high affinity of serum albumin for 16 and 18 carbon aliphatic chains.

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BT - Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium

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ER -

ALBUMIN RETENTION OF C//1//8 ALKYLATED BIOMER VASCULAR GRAFTS.

Abstract

ASJC Scopus subject areas

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