Alcoholic Hepatitis: Risk Factors, Pathogenesis, and Approach to Treatment

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Alcoholic hepatitis (AH) is an inflammatory disorder of the liver characterized clinically by jaundice, hepatomegaly, and abdominal pain, and histologically by macrovesicular steatosis and necroinflammation. Methods: This clinical review will cover what is known about the pathogenesis, clinical presentation, current treatments, and novel therapies for AH. Results: The pathogenesis and treatment of AH remain areas of active research. Although abstinence is the cornerstone of therapy for all stages of alcoholic liver disease, corticosteroids have shown modest short-term benefits in treatment of severe AH. Conclusions: Improved understanding of the pathogenesis of AH has expanded the range of potential treatments for this devastating disease. Several novel therapies are also currently in various stages of testing through clinical trials.

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume40
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • Alcoholic Hepatitis
  • Alcoholic Liver Disease
  • Ethanol
  • Fatty Liver
  • Innate Immune Response

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

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