Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function

P. C. White, A. Hautanen, M. Kupari

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume69
Issue number1-6
DOIs
StatePublished - Apr 1999

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Cytochrome P-450 CYP11B2
Aldosterone
Polymorphism
Alleles
Steroidogenic Factor 1
Baroreflex
Cardiovascular System
Cardiovascular system
Sodium
Myocardial Infarction
Blood pressure
Blood Pressure
Kidney
Gene Expression
Gene expression
Genes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function. / White, P. C.; Hautanen, A.; Kupari, M.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 69, No. 1-6, 04.1999, p. 409-412.

Research output: Contribution to journalArticle

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