TY - JOUR
T1 - Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function
AU - White, P. C.
AU - Hautanen, A.
AU - Kupari, M.
N1 - Funding Information:
We thank our colleagues who participated in unpublished work cited in this report, including Antti Ylitalo, K.E. Juhani Airaksinen, Marion Carson, Juha Virolainen, Markku Savolainen, Heikki Kauma, Y. Antero Kesäniemi, Heikki V. Huikuri, Petri Toivanen, Matti Mänttäri, Leena Tenkanen, V. Manninen, and Kathleen Kayes. This work was supported by NIH Grant R37 DK37867.
PY - 1999/4
Y1 - 1999/4
N2 - In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.
AB - In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.
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U2 - 10.1016/S0960-0760(99)00071-0
DO - 10.1016/S0960-0760(99)00071-0
M3 - Article
C2 - 10419019
AN - SCOPUS:0033017526
SN - 0960-0760
VL - 69
SP - 409
EP - 412
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
IS - 1-6
ER -