Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function

P. C. White, A. Hautanen, M. Kupari

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume69
Issue number1-6
DOIs
StatePublished - Apr 1 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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