Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function

P. C. White, A. Hautanen, M. Kupari

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.

Original languageEnglish (US)
Pages (from-to)797-804
Number of pages8
JournalEndocrine Research
Volume24
Issue number3-4
StatePublished - 1998

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Cytochrome P-450 CYP11B2
Aldosterone
Alleles
Steroidogenic Factor 1
Baroreflex
Cardiovascular System
Sodium
Myocardial Infarction
Blood Pressure
Kidney
Gene Expression
Genes

ASJC Scopus subject areas

  • Endocrinology

Cite this

Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function. / White, P. C.; Hautanen, A.; Kupari, M.

In: Endocrine Research, Vol. 24, No. 3-4, 1998, p. 797-804.

Research output: Contribution to journalArticle

White, PC, Hautanen, A & Kupari, M 1998, 'Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function', Endocrine Research, vol. 24, no. 3-4, pp. 797-804.
White, P. C. ; Hautanen, A. ; Kupari, M. / Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function. In: Endocrine Research. 1998 ; Vol. 24, No. 3-4. pp. 797-804.
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