Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function

P. C. White, A. Hautanen, M. Kupari

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.

Original languageEnglish (US)
Pages (from-to)797-804
Number of pages8
JournalEndocrine Research
Volume24
Issue number3-4
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Endocrinology

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