Alemtuzumab induction and recurrence of glomerular disease after kidney transplantation

Julio Pascual, Joshua D. Mezrich, Arjang Djamali, Glen Leverson, L. Thomas Chin, José Torrealba, Debra Bloom, Barbara Voss, Bryan N. Becker, Stuart J. Knechtle, Hans W. Sollinger, John D. Pirsch, Milagros D. Samaniego

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24 Scopus citations

Abstract

BACKGROUND. An increase in the incidence of autoimmune diseases has been described in patients receiving alemtuzumab. METHODS. To determine whether induction with alemtuzumab increases recurrence of glomerular disease, we performed a retrospective study in 443 patients with biopsy-proven glomerular diseases undergoing kidney transplantation. Patients receiving alemtuzumab (n=161) were compared with those receiving interleukin (IL)-2-receptor antagonists (n=217) or antithymocyte globulin (n=64). RESULTS. Biopsy-proven glomerular disease recurrence was similar in patients induced with alemtuzumab or IL-2 receptor antagonists. Patients receiving antithymocyte antibody had a lower recurrence rate than patients treated with other induction agents, with borderline significance (hazard ratio [HR] 0.13, 95% confidence interval [95% CI] 0.02-0.98, P=0.047). Patients with systemic lupus treated with alemtuzumab had a similar re-emergence of autoreactive antibodies to patients treated with other agents. Recurrent disease increased the risk of allograft failure (HR 2.36, 95% CI 1.28-4.32, P=0.0056). The development of acute rejection and the use of deceased (vs. living) donor kidneys were also significant factors influencing graft survival. A greater risk of mortality was detected in those patients with recurrent glomerular disease (HR 3.76, 95% CI 1.37-10.35, P=0.01), whereas increased age at transplantation (HR 1.05) and the use of deceased (vs. living) donor kidneys (HR 3.20) also increased mortality. No specific induction agent significantly affected graft loss or mortality when using adjusted or unadjusted hazard ratios. CONCLUSIONS. In this retrospective analysis, induction with alemtuzumab did not increase the rate of re-emergence of autoantibodies or biopsy-proven recurrence of glomerular disease. A slight reduction in the incidence of recurrence was observed in patients treated with thymoglobulin, yet this observation can only be validated in a prospective randomized trial.

Original languageEnglish (US)
Pages (from-to)1429-1434
Number of pages6
JournalTransplantation
Volume83
Issue number11
DOIs
StatePublished - Jun 1 2007

Keywords

  • Alemtuzumab
  • Recurrent glomerulonephritis
  • Thymoglobulin

ASJC Scopus subject areas

  • Transplantation

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    Pascual, J., Mezrich, J. D., Djamali, A., Leverson, G., Chin, L. T., Torrealba, J., Bloom, D., Voss, B., Becker, B. N., Knechtle, S. J., Sollinger, H. W., Pirsch, J. D., & Samaniego, M. D. (2007). Alemtuzumab induction and recurrence of glomerular disease after kidney transplantation. Transplantation, 83(11), 1429-1434. https://doi.org/10.1097/01.tp.0000264554.39645.74