Alisertib induces G₂/M arrest, apoptosis, and autophagy via PI3K/Akt/mTOR-and p38 MAPK-mediated pathways in human glioblastoma cells

Medicine & Life Sciences

• MLN 8237 100%
• TOR Serine-Threonine Kinases 62%
• p38 Mitogen-Activated Protein Kinases 58%
• Phosphatidylinositol 3-Kinase 57%
• Glioblastoma 55%
• Autophagy 54%
• Apoptosis 34%
• Aurora Kinase A 16%
• Cyclin B1 14%
• Apoptosis Regulatory Proteins 13%
• Cytochromes 12%
• Adenosine Monophosphate 12%
• Protein Kinases 10%
• Caspase 3 10%
• Mitochondria 9%
• CDC2 Protein Kinase 8%
• Tensins 7%
• Beclin-1 7%
• Cell Cycle Proteins 6%
• Hydrogen Bonding 6%
• Microtubule-Associated Proteins 6%
• Proto-Oncogene Proteins c-akt 6%
• Caspase 9 6%
• Phosphoric Monoester Hydrolases 5%
• Antineoplastic Agents 5%
• Computational Biology 5%
• Brain Neoplasms 5%
• Light 3%
• Cell Proliferation 3%
• Cell Line 3%
• Growth 2%
• Animals 2%
• Neoplasms 1%
• Therapeutics 0%

Chemical Compounds

• Phosphatidylinositol 68%
• Protein 23%
• Aurora 17%
• Cytochrome C 15%
• Antiapoptotic 8%
• Adenosine 5%
• Antineoplastic Agent 5%
• Hydrogen Bond 3%