Alkaline Phosphatase: Keeping the Peace at the Gut Epithelial Surface

Shipra Vaishnava, Lora V. Hooper

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Vertebrate intestinal surfaces are in constant contact with a vast consortium of commensal bacteria. To preserve mutually beneficial host-microbial relationships, gut epithelia have evolved strategies to limit the proinflammatory potential of resident gut microbes. In this issue of Cell Host & Microbe, Bates and colleagues report that intestinal alkaline phosphatase, whose expression is induced during establishment of the microbiota, dephosphorylates lipopolysaccharide and promotes mucosal tolerance to commensal bacteria in zebrafish.

Original languageEnglish (US)
Pages (from-to)365-367
Number of pages3
JournalCell Host and Microbe
Volume2
Issue number6
DOIs
StatePublished - Dec 13 2007

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Alkaline Phosphatase
Bacteria
Microbiota
Zebrafish
Lipopolysaccharides
Vertebrates
Epithelium

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Alkaline Phosphatase : Keeping the Peace at the Gut Epithelial Surface. / Vaishnava, Shipra; Hooper, Lora V.

In: Cell Host and Microbe, Vol. 2, No. 6, 13.12.2007, p. 365-367.

Research output: Contribution to journalArticle

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