Alkaline Phosphatase: Keeping the Peace at the Gut Epithelial Surface

Shipra Vaishnava, Lora V. Hooper

Research output: Contribution to journalShort survey

43 Scopus citations

Abstract

Vertebrate intestinal surfaces are in constant contact with a vast consortium of commensal bacteria. To preserve mutually beneficial host-microbial relationships, gut epithelia have evolved strategies to limit the proinflammatory potential of resident gut microbes. In this issue of Cell Host & Microbe, Bates and colleagues report that intestinal alkaline phosphatase, whose expression is induced during establishment of the microbiota, dephosphorylates lipopolysaccharide and promotes mucosal tolerance to commensal bacteria in zebrafish.

Original languageEnglish (US)
Pages (from-to)365-367
Number of pages3
JournalCell Host and Microbe
Volume2
Issue number6
DOIs
StatePublished - Dec 13 2007

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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