TY - JOUR
T1 - Alkaline Phosphatase
T2 - Keeping the Peace at the Gut Epithelial Surface
AU - Vaishnava, Shipra
AU - Hooper, Lora V.
PY - 2007/12/13
Y1 - 2007/12/13
N2 - Vertebrate intestinal surfaces are in constant contact with a vast consortium of commensal bacteria. To preserve mutually beneficial host-microbial relationships, gut epithelia have evolved strategies to limit the proinflammatory potential of resident gut microbes. In this issue of Cell Host & Microbe, Bates and colleagues report that intestinal alkaline phosphatase, whose expression is induced during establishment of the microbiota, dephosphorylates lipopolysaccharide and promotes mucosal tolerance to commensal bacteria in zebrafish.
AB - Vertebrate intestinal surfaces are in constant contact with a vast consortium of commensal bacteria. To preserve mutually beneficial host-microbial relationships, gut epithelia have evolved strategies to limit the proinflammatory potential of resident gut microbes. In this issue of Cell Host & Microbe, Bates and colleagues report that intestinal alkaline phosphatase, whose expression is induced during establishment of the microbiota, dephosphorylates lipopolysaccharide and promotes mucosal tolerance to commensal bacteria in zebrafish.
UR - http://www.scopus.com/inward/record.url?scp=36749009597&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749009597&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2007.11.004
DO - 10.1016/j.chom.2007.11.004
M3 - Short survey
C2 - 18078687
AN - SCOPUS:36749009597
SN - 1931-3128
VL - 2
SP - 365
EP - 367
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 6
ER -