Alkaliptosis: a new weapon for cancer therapy

Jiao Liu, Feimei Kuang, Rui Kang, Daolin Tang

Research output: Contribution to journalEditorial

Abstract

Malignant tumors are one of the major causes of death worldwide, and the development of better treatments is urgently needed. There are many types of cancer treatment, such as surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapy, that might improve patient outcomes in a genotype- and stage-dependent manner. The main goal of cancer therapy is to inhibit biological capabilities of tumors and eventually eliminate the cancer cells. However, cancer cells are well known to escape apoptosis, a form of programmed cell death that was first described in studies of cell development and tissue remodelling. Increasing our understanding of cell death may result in new anticancer approaches that target types of nonapoptotic cell death, such as necroptosis, ferroptosis, autophagy-dependent cell death, and alkaliptosis. Notably, alkaliptosis, a pH-dependent form of regulated cell death, has been recently identified as a new strategy for cancer therapy across multiple tumor types, especially in pancreatic cancer.

Original languageEnglish (US)
JournalCancer Gene Therapy
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Weapons
Cell Death
Neoplasms
Therapeutics
Autophagy
Pancreatic Neoplasms
Immunotherapy
Cause of Death
Radiotherapy
Genotype
Apoptosis
Drug Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

Cite this

Alkaliptosis : a new weapon for cancer therapy. / Liu, Jiao; Kuang, Feimei; Kang, Rui; Tang, Daolin.

In: Cancer Gene Therapy, 01.01.2019.

Research output: Contribution to journalEditorial

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