Allele-dependent recombination frequency: Homology requirement in meiotic recombination at the hot spot in the mouse major histocompatibility complex

Masayasu Yoshino, Tomoko Sagai, Kirsten Fischer Lindahl, Yutaka Toyoda, Kazuo Moriwaki, Toshihiko Shiroishi

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Meiotic recombination break joints in the mouse major histocompatibility complex (MHC) are clustered within short segments known as hot spots. We systematically investigated the requirement for sequence homology between two chromosomes for recombination activity at the hot spot next to the Lmp2 gene. The results indicated that a high rate of recombination required a high degree of similarity of overall genome structure at the hot spot. In particular, the same copy number of repetitive sequences within the hot spot was essential for a high frequency of recombination, suggesting that recombination in mouse meiosis is more sensitive to heterozygous deletion or insertion of DNA than to mismatches of single-base substitutions.

Original languageEnglish (US)
Pages (from-to)298-305
Number of pages8
JournalGenomics
Volume27
Issue number2
DOIs
StatePublished - May 20 1995

ASJC Scopus subject areas

  • Genetics

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