Abstract
Meiotic recombination break joints in the mouse major histocompatibility complex (MHC) are clustered within short segments known as hot spots. We systematically investigated the requirement for sequence homology between two chromosomes for recombination activity at the hot spot next to the Lmp2 gene. The results indicated that a high rate of recombination required a high degree of similarity of overall genome structure at the hot spot. In particular, the same copy number of repetitive sequences within the hot spot was essential for a high frequency of recombination, suggesting that recombination in mouse meiosis is more sensitive to heterozygous deletion or insertion of DNA than to mismatches of single-base substitutions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 298-305 |
| Number of pages | 8 |
| Journal | Genomics |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 20 1995 |
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ASJC Scopus subject areas
- Genetics
Cite this
Allele-Dependent Recombination Frequency : Homology Requirement in Meiotic Recombination at the Hot Spot in the Mouse Major Histocompatibility Complex. / Yoshino, Masayasu; Sagai, Tomoko; Lindahl, Kirsten Fischer; Toyoda, Yutaka; Moriwaki, Kazuo; Shiroishi, Toshihiko.
In: Genomics, Vol. 27, No. 2, 20.05.1995, p. 298-305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Allele-Dependent Recombination Frequency
T2 - Homology Requirement in Meiotic Recombination at the Hot Spot in the Mouse Major Histocompatibility Complex
AU - Yoshino, Masayasu
AU - Sagai, Tomoko
AU - Lindahl, Kirsten Fischer
AU - Toyoda, Yutaka
AU - Moriwaki, Kazuo
AU - Shiroishi, Toshihiko
PY - 1995/5/20
Y1 - 1995/5/20
N2 - Meiotic recombination break joints in the mouse major histocompatibility complex (MHC) are clustered within short segments known as hot spots. We systematically investigated the requirement for sequence homology between two chromosomes for recombination activity at the hot spot next to the Lmp2 gene. The results indicated that a high rate of recombination required a high degree of similarity of overall genome structure at the hot spot. In particular, the same copy number of repetitive sequences within the hot spot was essential for a high frequency of recombination, suggesting that recombination in mouse meiosis is more sensitive to heterozygous deletion or insertion of DNA than to mismatches of single-base substitutions.
AB - Meiotic recombination break joints in the mouse major histocompatibility complex (MHC) are clustered within short segments known as hot spots. We systematically investigated the requirement for sequence homology between two chromosomes for recombination activity at the hot spot next to the Lmp2 gene. The results indicated that a high rate of recombination required a high degree of similarity of overall genome structure at the hot spot. In particular, the same copy number of repetitive sequences within the hot spot was essential for a high frequency of recombination, suggesting that recombination in mouse meiosis is more sensitive to heterozygous deletion or insertion of DNA than to mismatches of single-base substitutions.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029009080&partnerID=8YFLogxK
U2 - 10.1006/geno.1995.1046
DO - 10.1006/geno.1995.1046
M3 - Article
C2 - 7557996
AN - SCOPUS:0029009080
VL - 27
SP - 298
EP - 305
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -