Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions

Medicine & Life Sciences

• Ataxin-3 100%
• Nucleic Acids 59%
• Alleles 44%
• RNA 41%
• Base Pairing 18%
• Trinucleotide Repeats 16%
• Catalysis 7%
• Gene Silencing 6%
• Oligonucleotides 6%
• RNA Interference 5%
• Genes 4%
• DNA 3%

Chemical Compounds

• Nucleic Acid 50%
• Substitution Reaction 37%
• Flexibility 10%
• Silencing RNA 8%
• Molecular Recognition 6%
• Oligonucleotide 5%
• Cleavage 4%
• Catalysis 4%
• Strength 4%
• Application 2%