Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation

Engineering & Materials Science

• Phosphorylation 100%
• T-cells 92%
• Scaffolds 73%
• Proteins 56%
• Chemical activation 55%
• Modulation 47%
• Membranes 16%
• Signal transduction 7%
• Catalysis 6%

Medicine & Life Sciences

• Intrinsically Disordered Proteins 90%
• Phosphorylation 43%
• T-Lymphocytes 38%
• T-Cell Antigen Receptor 19%
• Tyrosine 17%
• Membranes 14%
• Signal Transduction 9%
• src Homology Domains 7%
• Catalysis 7%
• Proteins 6%
• Cell Communication 5%
• Kinetics 4%
• Mutation 3%

Chemical Compounds

• Protein 25%
• Tyrosine 14%
• Kd 11%
• Tyrosine Residue 8%
• Signal Transduction 8%
• Statistical Ensemble 7%
• Mutation 6%
• Catalysis 4%