Alteration of the cystic fibrosis transmembrane conductance regulator folding pathway: Effects of the ΔF508 mutation on the thermodynamic stability and folding yield of NBD1

Medicine & Life Sciences

• Cystic Fibrosis Transmembrane Conductance Regulator 100%
• Thermodynamics 96%
• Cystic Fibrosis 51%
• Mutation 44%
• Nucleotides 42%
• Sequence Deletion 30%
• Phenylalanine 29%
• Mutant Proteins 28%
• Temperature 18%
• Epithelial Cells 18%
• Phenotype 15%
• Membranes 15%
• In Vitro Techniques 11%

Chemical Compounds

• Mutation 67%
• Thermodynamics 48%
• Nucleotide 32%
• Reaction Yield 32%
• Phenylalanine 19%
• Monomer 11%
• Protein 8%