Alterations in chemokine expression following Theiler's virus infection and restraint stress

W. Mi, M. Belyavskyi, R. R. Johnson, A. N. Sieve, R. Storts, M. W. Meagher, C. J R Welsh

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1ß, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.

Original languageEnglish (US)
Pages (from-to)103-115
Number of pages13
JournalJournal of Neuroimmunology
Volume151
Issue number1-2
DOIs
StatePublished - Jun 2004

Keywords

  • Chemokine
  • Stress
  • Theiler's virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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