Alterations in chemokine expression following Theiler's virus infection and restraint stress

W. Mi; M. Belyavskyi; R. R. Johnson; A. N. Sieve; R. Storts; M. W. Meagher; C. J R Welsh

doi:10.1016/j.jneuroim.2004.02.010

Alterations in chemokine expression following Theiler's virus infection and restraint stress

W. Mi, M. Belyavskyi, R. R. Johnson, A. N. Sieve, R. Storts, M. W. Meagher, C. J R Welsh

Neurology & Neurotherapeutics

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1ß, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.

Original language	English (US)
Pages (from-to)	103-115
Number of pages	13
Journal	Journal of Neuroimmunology
Volume	151
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.02.010
State	Published - Jun 2004

Keywords

Chemokine
Stress
Theiler's virus

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2004.02.010

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title = "Alterations in chemokine expression following Theiler's virus infection and restraint stress",

abstract = "Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1{\ss}, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.",

keywords = "Chemokine, Stress, Theiler's virus",

author = "W. Mi and M. Belyavskyi and Johnson, {R. R.} and Sieve, {A. N.} and R. Storts and Meagher, {M. W.} and Welsh, {C. J R}",

note = "Funding Information: The authors acknowledge Lin Bustamante for the excellent technical assistance with the preparation of H&E sections, Dana D. Dean for assistance with photographs and Dr. Colin R. Young for the critical review of this manuscript. This research was funded by grants to C.J.R.W. and M.W.M. from the National Multiple Sclerosis Society RG 3128 and NIH/NINDS R01 39569, and supported, in part, by a Texas A&M University Life Sciences Task Force Training Grant to W.M.",

year = "2004",

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doi = "10.1016/j.jneuroim.2004.02.010",

language = "English (US)",

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AU - Mi, W.

AU - Belyavskyi, M.

AU - Johnson, R. R.

AU - Sieve, A. N.

AU - Storts, R.

AU - Meagher, M. W.

AU - Welsh, C. J R

N1 - Funding Information: The authors acknowledge Lin Bustamante for the excellent technical assistance with the preparation of H&E sections, Dana D. Dean for assistance with photographs and Dr. Colin R. Young for the critical review of this manuscript. This research was funded by grants to C.J.R.W. and M.W.M. from the National Multiple Sclerosis Society RG 3128 and NIH/NINDS R01 39569, and supported, in part, by a Texas A&M University Life Sciences Task Force Training Grant to W.M.

PY - 2004/6

Y1 - 2004/6

N2 - Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1ß, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.

AB - Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1ß, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.

KW - Chemokine

KW - Stress

KW - Theiler's virus

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Alterations in chemokine expression following Theiler's virus infection and restraint stress

Abstract

Keywords

ASJC Scopus subject areas

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