Alterations in hippocampal function in schizophrenia: Its genetic associations and systems implications

Subroto Ghose, Carol A. Tamminga

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Schizophrenia is characterized by a constellation of symptoms that include psychosis, cognitive deficits and negative symptoms. This has been verified in several investigations using factor analysis of large schizophrenic patient populations showing these distinct domains of dysfunction. When clinical symptoms are related to imaging findings, specific brain areas are found to be differentially involved in symptom domains in the illness (Liddle 1987; Carpenter and Buchanan 1989; Kay and Sevy 1990; Arndt et al. 1991; Lenzenweger et al. 1991; Barnes and Liddle 1990; Andreasen et al 1995), with prefrontal (PFC) most involved in executive function and medial temporal lobe (MTL) most associated with declarative memory. Studies defining the anatomy of schizophrenia show delimited regions of brain associated with the symptoms; these include the prefrontal cortex (both dorsolateral prefrontal cortex, DLPFC, and anterior cingulate cortex, ACC) and the MTL as well as the superior temporal gyrus (STG). In this chapter, we review a large and significant body of convergent evidence that demonstrates the importance of the medial temporal lobe as a brain region central to the pathophysiology of schizophrenia.

Original languageEnglish (US)
Title of host publicationCortical Deficits in Schizophrenia
Subtitle of host publicationFrom Genes to Function
PublisherSpringer US
Pages157-190
Number of pages34
ISBN (Electronic)9780387743516
ISBN (Print)9780387743509
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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    Ghose, S., & Tamminga, C. A. (2008). Alterations in hippocampal function in schizophrenia: Its genetic associations and systems implications. In Cortical Deficits in Schizophrenia: From Genes to Function (pp. 157-190). Springer US. https://doi.org/10.1007/978-0-387-74351-6_8