Objective: To determine if thermal injury alters the expression of leukocyte adhesion molecules. Design: This is a controlled experimental animal study. Materials and Methods: Partial thickness burns were created on the backs of New Zealand White rabbits. At 30 minutes, 2 hours, 4 hours, and 24 hours after burn, skin was harvested for immunohistochemistry. Monoclonal antibodies were used to study changes in intercellular adhesion molecule 1 (ICAM-1), E-selectin, and leukocyte CD11a. Staining was graded on a scale of 0 to 4. Measurements and Main Results: ICAM-1 was significantly decreased at 24 hours after burn (p < 0.007, Wilcoxon signed rank test). CD11a was increased at 30 minutes (p < 0.02), 2 hours (p < 0.02), and 24 hours (p < 0.006). E-selectin was increased at 2 hours (p < 0.03). Conclusion: Thermal injury alters the expression of leukocyte adhesion molecules.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Trauma - Injury, Infection and Critical Care|
|State||Published - Sep 12 1995|
- Intercellular adhesion molecule (ICAM)
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine