Alterations in lower reproductive tract flora after single-dose piperacillin and triple-dose cefoxitin at vaginal and abdominal hysterectomy

D. L. Hemsell, M. C. Heard, P. G. Hemsell, B. J. Nobles, R. E. Bawdon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There are no current data regarding the effect of a newer, broad-spectrum penicillin on lower reproductive flora at hysterectomy. To identify any existing differential effect on species and their susceptibilities, we obtained pre- and postoperative lower reproductive tract culture material from 209 women who were given single-dose piperacillin, then placebo or triple-dose cefoxitin, intravenously for prophylaxis at vaginal and abdominal hysterectomy in a prospective, randomized, blinded clinical trial. Significantly more preoperative endocervical bacteria were susceptible to piperacillin. Piperacillin caused less alteration in the numbers of lower reproductive tract flora when preoperative species were compared with postoperative species. More resistance to cefoxitin was identified postoperatively in bacteria recovered from the vaginal cuff of women who remained uninfected.

Original languageEnglish (US)
Pages (from-to)875-880
Number of pages6
JournalObstetrics and Gynecology
Volume72
Issue number6
StatePublished - 1988

Fingerprint

Vaginal Hysterectomy
Cefoxitin
Piperacillin
Bacteria
Hysterectomy
Penicillins
Randomized Controlled Trials
Placebos

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Alterations in lower reproductive tract flora after single-dose piperacillin and triple-dose cefoxitin at vaginal and abdominal hysterectomy. / Hemsell, D. L.; Heard, M. C.; Hemsell, P. G.; Nobles, B. J.; Bawdon, R. E.

In: Obstetrics and Gynecology, Vol. 72, No. 6, 1988, p. 875-880.

Research output: Contribution to journalArticle

@article{d02eb06e3185472aa50e0df5c534f273,
title = "Alterations in lower reproductive tract flora after single-dose piperacillin and triple-dose cefoxitin at vaginal and abdominal hysterectomy",
abstract = "There are no current data regarding the effect of a newer, broad-spectrum penicillin on lower reproductive flora at hysterectomy. To identify any existing differential effect on species and their susceptibilities, we obtained pre- and postoperative lower reproductive tract culture material from 209 women who were given single-dose piperacillin, then placebo or triple-dose cefoxitin, intravenously for prophylaxis at vaginal and abdominal hysterectomy in a prospective, randomized, blinded clinical trial. Significantly more preoperative endocervical bacteria were susceptible to piperacillin. Piperacillin caused less alteration in the numbers of lower reproductive tract flora when preoperative species were compared with postoperative species. More resistance to cefoxitin was identified postoperatively in bacteria recovered from the vaginal cuff of women who remained uninfected.",
author = "Hemsell, {D. L.} and Heard, {M. C.} and Hemsell, {P. G.} and Nobles, {B. J.} and Bawdon, {R. E.}",
year = "1988",
language = "English (US)",
volume = "72",
pages = "875--880",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Alterations in lower reproductive tract flora after single-dose piperacillin and triple-dose cefoxitin at vaginal and abdominal hysterectomy

AU - Hemsell, D. L.

AU - Heard, M. C.

AU - Hemsell, P. G.

AU - Nobles, B. J.

AU - Bawdon, R. E.

PY - 1988

Y1 - 1988

N2 - There are no current data regarding the effect of a newer, broad-spectrum penicillin on lower reproductive flora at hysterectomy. To identify any existing differential effect on species and their susceptibilities, we obtained pre- and postoperative lower reproductive tract culture material from 209 women who were given single-dose piperacillin, then placebo or triple-dose cefoxitin, intravenously for prophylaxis at vaginal and abdominal hysterectomy in a prospective, randomized, blinded clinical trial. Significantly more preoperative endocervical bacteria were susceptible to piperacillin. Piperacillin caused less alteration in the numbers of lower reproductive tract flora when preoperative species were compared with postoperative species. More resistance to cefoxitin was identified postoperatively in bacteria recovered from the vaginal cuff of women who remained uninfected.

AB - There are no current data regarding the effect of a newer, broad-spectrum penicillin on lower reproductive flora at hysterectomy. To identify any existing differential effect on species and their susceptibilities, we obtained pre- and postoperative lower reproductive tract culture material from 209 women who were given single-dose piperacillin, then placebo or triple-dose cefoxitin, intravenously for prophylaxis at vaginal and abdominal hysterectomy in a prospective, randomized, blinded clinical trial. Significantly more preoperative endocervical bacteria were susceptible to piperacillin. Piperacillin caused less alteration in the numbers of lower reproductive tract flora when preoperative species were compared with postoperative species. More resistance to cefoxitin was identified postoperatively in bacteria recovered from the vaginal cuff of women who remained uninfected.

UR - http://www.scopus.com/inward/record.url?scp=0024162302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024162302&partnerID=8YFLogxK

M3 - Article

C2 - 3054651

AN - SCOPUS:0024162302

VL - 72

SP - 875

EP - 880

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 6

ER -