Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects

Shannon B. Juengst, Howard J. Aizenstein, Jennifer Figurski, Oscar L. Lopez, James T. Becker

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) has revealed much about altered CNS function in HIV/AIDS. In this study, we compared the blood oxygen level dependent hemodynamic response function (BOLD HRF) signal in HIV/AIDS and control subjects as a necessary pre-condition for fMRI studies of higher level cognitive function. Using event-related fMRI, subjects performed a simple sensory-motor activity allowing the measurement of the BOLD HRF in the precentral gyrus. There were no significant differences in the HRF when viewed as a function of age, hemisphere, or HIV serostatus. However, significant results were found after dividing the subjects by NIMH impairment classifications. There were 16 control subjects, 19 Normal/Asymptomatic Neuropsychological Impairment (ANI), and 11 Minor Neurocognitive Disorder (MNCD)/HIV-Associated Dementia (HAD) subjects. The HRF of MNCD/HAD subjects did not return to baseline after 16 s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalJournal of Neuroscience Methods
Volume163
Issue number2
DOIs
StatePublished - Jul 30 2007

Keywords

  • Aging
  • BOLD response
  • Cognitive impairment
  • HIV
  • Hemodynamic response function
  • Neuropsychological impairment
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)

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