Alterations of the PPP2R1B gene in human lung and colon cancer

Steven Siqing Wang, Edward D. Esplin, Jia Ling Li, Liying Huang, Adi Gazdar, John Minna, Glen A. Evans

Research output: Contribution to journalArticle

312 Citations (Scopus)

Abstract

The PPP2R1B gene, which encodes the β isoform of the A subunit of the serine/threonine protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene. Sequencing of the PPP2R1B gene, located on human chromosome 11q22-24, revealed somatic alterations in 15% (5 out of 33) of primary lung tumors, 6% (4 out of 70) of lung tumor-derived cell lines, and 15% (2 out of 13) of primary colon tumors. One deletion mutation generated a truncated PP2A-Aβ protein that was unable to bind to the catalytic subunit of the PP2A holoenzyme. The PP2R1B gene product may suppress tumor development through its role in cell cycle regulation and cellular growth control.

Original languageEnglish (US)
Pages (from-to)284-287
Number of pages4
JournalScience
Volume282
Issue number5387
DOIs
StatePublished - Oct 9 1998

Fingerprint

Protein Phosphatase 2
Colonic Neoplasms
Lung Neoplasms
Genes
Neoplasms
Lung
Holoenzymes
Sequence Deletion
Human Chromosomes
Threonine
Tumor Cell Line
Tumor Suppressor Genes
Serine
Catalytic Domain
Cell Cycle
Protein Isoforms
Colon
Growth
Proteins

ASJC Scopus subject areas

  • General

Cite this

Wang, S. S., Esplin, E. D., Li, J. L., Huang, L., Gazdar, A., Minna, J., & Evans, G. A. (1998). Alterations of the PPP2R1B gene in human lung and colon cancer. Science, 282(5387), 284-287. https://doi.org/10.1126/science.282.5387.284

Alterations of the PPP2R1B gene in human lung and colon cancer. / Wang, Steven Siqing; Esplin, Edward D.; Li, Jia Ling; Huang, Liying; Gazdar, Adi; Minna, John; Evans, Glen A.

In: Science, Vol. 282, No. 5387, 09.10.1998, p. 284-287.

Research output: Contribution to journalArticle

Wang, SS, Esplin, ED, Li, JL, Huang, L, Gazdar, A, Minna, J & Evans, GA 1998, 'Alterations of the PPP2R1B gene in human lung and colon cancer', Science, vol. 282, no. 5387, pp. 284-287. https://doi.org/10.1126/science.282.5387.284
Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J et al. Alterations of the PPP2R1B gene in human lung and colon cancer. Science. 1998 Oct 9;282(5387):284-287. https://doi.org/10.1126/science.282.5387.284
Wang, Steven Siqing ; Esplin, Edward D. ; Li, Jia Ling ; Huang, Liying ; Gazdar, Adi ; Minna, John ; Evans, Glen A. / Alterations of the PPP2R1B gene in human lung and colon cancer. In: Science. 1998 ; Vol. 282, No. 5387. pp. 284-287.
@article{ca4fbb11a96f424f8c45caaca7ab9bc2,
title = "Alterations of the PPP2R1B gene in human lung and colon cancer",
abstract = "The PPP2R1B gene, which encodes the β isoform of the A subunit of the serine/threonine protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene. Sequencing of the PPP2R1B gene, located on human chromosome 11q22-24, revealed somatic alterations in 15{\%} (5 out of 33) of primary lung tumors, 6{\%} (4 out of 70) of lung tumor-derived cell lines, and 15{\%} (2 out of 13) of primary colon tumors. One deletion mutation generated a truncated PP2A-Aβ protein that was unable to bind to the catalytic subunit of the PP2A holoenzyme. The PP2R1B gene product may suppress tumor development through its role in cell cycle regulation and cellular growth control.",
author = "Wang, {Steven Siqing} and Esplin, {Edward D.} and Li, {Jia Ling} and Liying Huang and Adi Gazdar and John Minna and Evans, {Glen A.}",
year = "1998",
month = "10",
day = "9",
doi = "10.1126/science.282.5387.284",
language = "English (US)",
volume = "282",
pages = "284--287",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5387",

}

TY - JOUR

T1 - Alterations of the PPP2R1B gene in human lung and colon cancer

AU - Wang, Steven Siqing

AU - Esplin, Edward D.

AU - Li, Jia Ling

AU - Huang, Liying

AU - Gazdar, Adi

AU - Minna, John

AU - Evans, Glen A.

PY - 1998/10/9

Y1 - 1998/10/9

N2 - The PPP2R1B gene, which encodes the β isoform of the A subunit of the serine/threonine protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene. Sequencing of the PPP2R1B gene, located on human chromosome 11q22-24, revealed somatic alterations in 15% (5 out of 33) of primary lung tumors, 6% (4 out of 70) of lung tumor-derived cell lines, and 15% (2 out of 13) of primary colon tumors. One deletion mutation generated a truncated PP2A-Aβ protein that was unable to bind to the catalytic subunit of the PP2A holoenzyme. The PP2R1B gene product may suppress tumor development through its role in cell cycle regulation and cellular growth control.

AB - The PPP2R1B gene, which encodes the β isoform of the A subunit of the serine/threonine protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene. Sequencing of the PPP2R1B gene, located on human chromosome 11q22-24, revealed somatic alterations in 15% (5 out of 33) of primary lung tumors, 6% (4 out of 70) of lung tumor-derived cell lines, and 15% (2 out of 13) of primary colon tumors. One deletion mutation generated a truncated PP2A-Aβ protein that was unable to bind to the catalytic subunit of the PP2A holoenzyme. The PP2R1B gene product may suppress tumor development through its role in cell cycle regulation and cellular growth control.

UR - http://www.scopus.com/inward/record.url?scp=0032500792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032500792&partnerID=8YFLogxK

U2 - 10.1126/science.282.5387.284

DO - 10.1126/science.282.5387.284

M3 - Article

C2 - 9765152

AN - SCOPUS:0032500792

VL - 282

SP - 284

EP - 287

JO - Science

JF - Science

SN - 0036-8075

IS - 5387

ER -