Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

David Marlevi, Jorge Mariscal-Harana, Nicholas S. Burris, Julio Sotelo, Bram Ruijsink, Myrianthi Hadjicharalambous, Liya Asner, Eva Sammut, Radomir Chabiniok, Sergio Uribe, Reidar Winter, Pablo Lamata, Jordi Alastruey, David Nordsletten

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr: [Figure not available: see fulltext.].

Original languageEnglish (US)
JournalJournal of cardiovascular translational research
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Keywords

  • 4D flow MRI
  • Aortic hemodynamics
  • Aortic relative pressure
  • Aortic stiffness
  • Dilated cardiomyopathy

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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