Altered B-cell signaling in lupus

Kui Liu, Chandra Mohan

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of complex etiology primarily characterized by the presence of high titers of autoantibodies targeting many nuclear as well as cytoplasmic antigens, with resultant end-organ damage. Aberrant signaling events have been documented in various lymphocyte populations, and they have constituted attractive targets for therapeutic intervention. Murine models of lupus (conventional or engineered) have yielded interesting snapshots of the signaling status of lupus lymphocytes, and many of these alterations in cell signaling observed in murine models of lupus have also been documented in patient samples. Analyses of B-cell signaling in various murine lupus models have not only provided an in-depth perspective of the signaling status and possibly the underlying mechanisms leading to enhanced survival of autoimmune B cells, but have also presented us with potential strategies for treating lupus.

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalAutoimmunity Reviews
Volume8
Issue number3
DOIs
StatePublished - Jan 1 2009

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Keywords

  • B cell
  • Lupus
  • Signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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