Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets

Junfeng Bi, Sudhir Chowdhry, Sihan Wu, Wenjing Zhang, Kenta Masui, Paul S. Mischel

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent technological advances, new insights into the molecular mechanisms underlying glioma metabolism are rapidly emerging. In this Review, we focus on the dynamic nature of glioma metabolism and how it is shaped by the interaction between tumour genotype and brain microenvironment. Recent advances integrating metabolomics with genomics are discussed, yielding new insight into the mechanisms that drive glioma pathogenesis. Studies that shed light on interactions between the tumour microenvironment and tumour genotype are highlighted, providing important clues as to how gliomas respond to and adapt to their changing tissue and biochemical contexts. Finally, a road map for the discovery of potential new glioma drug targets is suggested, with the goal of translating these new insights about glioma metabolism into clinical benefits for patients.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalNature Reviews Cancer
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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