Altered Neural Processing of Threat in Alcohol-Dependent Men

Hongyu Yang, Michael D. Devous, Richard W. Briggs, Jeffrey S. Spence, Hong Xiao, Nicholas Kreyling, Bryon Adinoff

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Stress-response biological systems are altered in alcohol-dependent individuals and are reported to predict future relapse. This study was designed to assess neural disruptions in alcohol-dependent participants when exposed to a conditioned stimulus (CS) warning of the impending onset of a universal, nonpersonalized stressor. Methods: Fifteen alcohol-dependent men abstinent for 3 to 5 weeks and 15 age- and race-similar healthy controls were studied. Anticipatory anxiety was induced by a CS paired with an uncertain, physically painful unconditioned stressor. Neural response was assessed using functional magnetic resonance imaging. Results: Both groups experienced significant, similar levels of anticipatory anxiety in response to the high-threat relative to the low-threat CS. Whereas control participants markedly increased the blood oxygen level-dependent (BOLD) amplitude in cortical-limbic-striatal regions during the high-threat, relative to low-threat, stimulus, alcohol-dependent participants decreased BOLD amplitude in the pregenual anterior cingulate cortex (pgACC), medial prefrontal cortex (mPFC), medial orbitofrontal cortex, posterior cingulate cortex (PCC), bilateral parietal/occipital cortex, and right hippocampus. Alcohol-dependent participants significantly deactivated pgACC/mPFC and PCC clusters, relative to controls, during the high- versus low-threat stimulus. This difference was due to a decrease in %BOLD amplitude during the high-threat stimulus in the alcohol-dependent, but not the control, participants. Conclusions: Alcohol-dependent men show cortical-limbic-striatal deactivation during anticipatory anxiety, particularly in regions associated with emotional regulation. These findings suggest a lack of engagement of affective regulatory mechanisms during high-stress situations in alcohol-dependent men.

Original languageEnglish (US)
Pages (from-to)2029-2038
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume37
Issue number12
DOIs
StatePublished - 2013

Fingerprint

Alcohols
Gyrus Cinguli
Processing
Prefrontal Cortex
Corpus Striatum
Blood
Anxiety
Oxygen
Occipital Lobe
Parietal Lobe
Biological systems
Hippocampus
Magnetic Resonance Imaging
Recurrence

Keywords

  • Alcoholism
  • Anticipatory Anxiety
  • Emotional Stress
  • Functional Magnetic Resonance Imaging
  • Striatal-Limbic-Cortical System

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Yang, H., Devous, M. D., Briggs, R. W., Spence, J. S., Xiao, H., Kreyling, N., & Adinoff, B. (2013). Altered Neural Processing of Threat in Alcohol-Dependent Men. Alcoholism: Clinical and Experimental Research, 37(12), 2029-2038. https://doi.org/10.1111/acer.12187

Altered Neural Processing of Threat in Alcohol-Dependent Men. / Yang, Hongyu; Devous, Michael D.; Briggs, Richard W.; Spence, Jeffrey S.; Xiao, Hong; Kreyling, Nicholas; Adinoff, Bryon.

In: Alcoholism: Clinical and Experimental Research, Vol. 37, No. 12, 2013, p. 2029-2038.

Research output: Contribution to journalArticle

Yang, H, Devous, MD, Briggs, RW, Spence, JS, Xiao, H, Kreyling, N & Adinoff, B 2013, 'Altered Neural Processing of Threat in Alcohol-Dependent Men', Alcoholism: Clinical and Experimental Research, vol. 37, no. 12, pp. 2029-2038. https://doi.org/10.1111/acer.12187
Yang H, Devous MD, Briggs RW, Spence JS, Xiao H, Kreyling N et al. Altered Neural Processing of Threat in Alcohol-Dependent Men. Alcoholism: Clinical and Experimental Research. 2013;37(12):2029-2038. https://doi.org/10.1111/acer.12187
Yang, Hongyu ; Devous, Michael D. ; Briggs, Richard W. ; Spence, Jeffrey S. ; Xiao, Hong ; Kreyling, Nicholas ; Adinoff, Bryon. / Altered Neural Processing of Threat in Alcohol-Dependent Men. In: Alcoholism: Clinical and Experimental Research. 2013 ; Vol. 37, No. 12. pp. 2029-2038.
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N2 - Background: Stress-response biological systems are altered in alcohol-dependent individuals and are reported to predict future relapse. This study was designed to assess neural disruptions in alcohol-dependent participants when exposed to a conditioned stimulus (CS) warning of the impending onset of a universal, nonpersonalized stressor. Methods: Fifteen alcohol-dependent men abstinent for 3 to 5 weeks and 15 age- and race-similar healthy controls were studied. Anticipatory anxiety was induced by a CS paired with an uncertain, physically painful unconditioned stressor. Neural response was assessed using functional magnetic resonance imaging. Results: Both groups experienced significant, similar levels of anticipatory anxiety in response to the high-threat relative to the low-threat CS. Whereas control participants markedly increased the blood oxygen level-dependent (BOLD) amplitude in cortical-limbic-striatal regions during the high-threat, relative to low-threat, stimulus, alcohol-dependent participants decreased BOLD amplitude in the pregenual anterior cingulate cortex (pgACC), medial prefrontal cortex (mPFC), medial orbitofrontal cortex, posterior cingulate cortex (PCC), bilateral parietal/occipital cortex, and right hippocampus. Alcohol-dependent participants significantly deactivated pgACC/mPFC and PCC clusters, relative to controls, during the high- versus low-threat stimulus. This difference was due to a decrease in %BOLD amplitude during the high-threat stimulus in the alcohol-dependent, but not the control, participants. Conclusions: Alcohol-dependent men show cortical-limbic-striatal deactivation during anticipatory anxiety, particularly in regions associated with emotional regulation. These findings suggest a lack of engagement of affective regulatory mechanisms during high-stress situations in alcohol-dependent men.

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