Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice

Carol A. Dudley, Claudia Erbel-Sieler, Sandi Jo Estill, Martin Reick, Paul Franken, SiNae Pitts, Steven L. McKnight

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

Animal behavior is synchronized to the 24-hour light:dark (LD) cycle by regulatory programs that produce circadian fluctuations in gene expression throughout the body. In mammals, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of the brain; its paralog, neuronal PAS domain protein 2 (NPAS2), performs a similar function in other forebrain sites. To investigate the role of NPAS2 in behavioral manifestations of circadian rhythm, we studied locomotor activity, sleep patterns, and adaptability to both light- and restricted food-driven entrainment in NPAS2-deficient mice. Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal LD and feeding conditions and that NPAS2 is critical for adaptability to food restriction.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalScience
Volume301
Issue number5631
DOIs
StatePublished - Jul 18 2003

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Sleep
Light
Food
Animal Behavior
Suprachiasmatic Nucleus
Photoperiod
Locomotion
Prosencephalon
Circadian Rhythm
Mammals
Transcription Factors
Gene Expression
Protein Domains
Mouse Npas2 protein
Brain

ASJC Scopus subject areas

  • General

Cite this

Dudley, C. A., Erbel-Sieler, C., Estill, S. J., Reick, M., Franken, P., Pitts, S., & McKnight, S. L. (2003). Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science, 301(5631), 379-383. https://doi.org/10.1126/science.1082795

Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. / Dudley, Carol A.; Erbel-Sieler, Claudia; Estill, Sandi Jo; Reick, Martin; Franken, Paul; Pitts, SiNae; McKnight, Steven L.

In: Science, Vol. 301, No. 5631, 18.07.2003, p. 379-383.

Research output: Contribution to journalArticle

Dudley, CA, Erbel-Sieler, C, Estill, SJ, Reick, M, Franken, P, Pitts, S & McKnight, SL 2003, 'Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice', Science, vol. 301, no. 5631, pp. 379-383. https://doi.org/10.1126/science.1082795
Dudley CA, Erbel-Sieler C, Estill SJ, Reick M, Franken P, Pitts S et al. Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science. 2003 Jul 18;301(5631):379-383. https://doi.org/10.1126/science.1082795
Dudley, Carol A. ; Erbel-Sieler, Claudia ; Estill, Sandi Jo ; Reick, Martin ; Franken, Paul ; Pitts, SiNae ; McKnight, Steven L. / Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. In: Science. 2003 ; Vol. 301, No. 5631. pp. 379-383.
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