TY - JOUR
T1 - Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice
AU - Dudley, Carol A.
AU - Erbel-Sieler, Claudia
AU - Estill, Sandi Jo
AU - Reick, Martin
AU - Franken, Paul
AU - Pitts, SiNae
AU - McKnight, Steven L.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/7/18
Y1 - 2003/7/18
N2 - Animal behavior is synchronized to the 24-hour light:dark (LD) cycle by regulatory programs that produce circadian fluctuations in gene expression throughout the body. In mammals, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of the brain; its paralog, neuronal PAS domain protein 2 (NPAS2), performs a similar function in other forebrain sites. To investigate the role of NPAS2 in behavioral manifestations of circadian rhythm, we studied locomotor activity, sleep patterns, and adaptability to both light- and restricted food-driven entrainment in NPAS2-deficient mice. Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal LD and feeding conditions and that NPAS2 is critical for adaptability to food restriction.
AB - Animal behavior is synchronized to the 24-hour light:dark (LD) cycle by regulatory programs that produce circadian fluctuations in gene expression throughout the body. In mammals, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of the brain; its paralog, neuronal PAS domain protein 2 (NPAS2), performs a similar function in other forebrain sites. To investigate the role of NPAS2 in behavioral manifestations of circadian rhythm, we studied locomotor activity, sleep patterns, and adaptability to both light- and restricted food-driven entrainment in NPAS2-deficient mice. Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal LD and feeding conditions and that NPAS2 is critical for adaptability to food restriction.
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U2 - 10.1126/science.1082795
DO - 10.1126/science.1082795
M3 - Article
C2 - 12843397
AN - SCOPUS:0038454431
SN - 0036-8075
VL - 301
SP - 379
EP - 383
JO - Science
JF - Science
IS - 5631
ER -