Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells

Dinesh S. Rao, Sarah V. Bradley, Priti D. Kumar, Teresa S. Hyun, Djenann Saint-Dic, Katherine Oravecz-Wilson, Celina G. Kleer, Theodora S. Ross

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

The clathrin-associated protein, Huntingtin Interacting Protein 1 (HIP1), is overexpressed in multiple human epithelial tumors. Here, we report that HIP1 is a novel oncoprotein that transforms cells. HIP1-transformed cells, in contrast to RasV12-transformed cells, have dysregulation of multiple receptors involved in clathrin trafficking. Examples include upregulation of the epidermal growth factor receptor (EGFR) and the transferrin receptor. Furthermore, accumulation of transferrin and EGF in the HIP1-transformed cells was increased, and breast tumors that had EGFR expressed also had HIP1 upregulated. Thus, HIP1 overexpression promotes tumor formation and is associated with a general alteration in receptor trafficking. HIP1 is the first endocytic protein to be directly implicated in tumor formation.

Original languageEnglish (US)
Pages (from-to)471-482
Number of pages12
JournalCancer Cell
Volume3
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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    Rao, D. S., Bradley, S. V., Kumar, P. D., Hyun, T. S., Saint-Dic, D., Oravecz-Wilson, K., Kleer, C. G., & Ross, T. S. (2003). Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells. Cancer Cell, 3(5), 471-482. https://doi.org/10.1016/S1535-6108(03)00107-7